• Do More People Have Celiac Disease in the North vs the South?

Do More People Have Celiac Disease in the North vs the South?

A higher proportion of persons living at latitudes of 35° North or greater have celiac disease or avoid gluten than persons living south of this latitude, researchers report in the June issue of Gastroenterology. This difference was independent of race or ethnicity, socioeconomic status, or body mass index. Several autoimmune

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  • What Causes Wheat Sensitivity in People Without Celiac Disease?

What Causes Wheat Sensitivity in People Without Celiac Disease?

Gluten-containing cereals have high concentrations of amylase-trypsin inhibitors (ATIs), which activate innate immunity via the toll-like receptor 4 (TLR4), researchers report in the April issue of Gastroenterology. These ATIs are resistant to proteases and heat, and increase intestinal inflammation by activating intestinal and mesenteric lymph node myeloid cells. Wheat is

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  • Is Nonceliac Gluten Sensitivity Real?

Is Nonceliac Gluten Sensitivity Real?

When patients with nonceliac gluten sensitivity (NCGS) unknowingly ingested small amounts of gluten for 1 week, they developed more severe abdominal pain and bloating that patients who ingested a matched placebo, researchers report in the September issue of Clinical Gastroenterology and Hepatology. The study provides evidence for a form of

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  • A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A Point of Care Test to Identify Patients With Celiac Disease Before Endoscopy

A rapid, point-of-care test for deamidated gliadin peptide antibody (DGP) identifies patients with celiac disease with similar levels of sensitivity and specificity as standard serologic analysis of antibodies to tissue transglutaminase (anti-tTG). Use of this test before endoscopy could identify the best candidates for duodenal biopsy analysis, leading to cost

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  • Celiac Disease Risk Not Affected by Early Diet

Celiac Disease Risk Not Affected by Early Diet

Two studies have shown that neither breastfeeding nor timing the start of gluten-containing foods makes a difference in development of celiac disease in children at risk. The AP reported that the studies, published October 2 in the New England Journal of Medicine, show that there is no early window of

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  • Can Dietary Changes Reduce Eosinophilic Esophagitis in Adults?

Can Dietary Changes Reduce Eosinophilic Esophagitis in Adults?

Dietary elimination is a successful treatment approach for adults with eosinophilic esophagitis (EoE), researchers report in the August issue of Clinical Gastroenterology and Hepatology. EoE is characterized by inflammation or swelling of the esophagus associated with infiltration of eosinophils. Aeroallergens and food allergens might be involved in pathogenesis. Dietary elimination therapy has

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  • Is Gluten the Culprit in Non-Celiac Gluten Sensitivity?

Is Gluten the Culprit in Non-Celiac Gluten Sensitivity?

Rapidly fermented poorly absorbed short-chain carbohydrates, rather than gluten or other wheat proteins, might cause gastrointestinal symptoms in people who do not have celiac disease but feel better on gluten-free diets, according to the August issue of Gastroenterology. Individuals with non-celiac gluten sensitivity (NCGS), do not have celiac disease (based on

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