Corticosteroids, but not TNF Antagonists, Associate With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases

Increasing age, comorbidities, and use of corticosteroids and other anti-inflammatory agents correlated with severe COVID-19 in patients with inflammatory bowel diseases (IBD), whereas treatment with tumor necrosis factor (TNF) antagonists did not, researchers report in Gastroenterology. Corticosteroids, immunomodulators (thiopurines, methotrexate), and biologic agents (TNF antagonists such as infliximab) are commonly

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Is Antibiotic Prophylaxis Necessary During EUS-FNA of Pancreatic Cystic Lesions?

Risk of infection is low in patients undergoing endoscopic ultrasound with fine-needle aspiration (EUS-FNA) of pancreatic cysts, researchers report from a randomized controlled trial published in Gastroenterology. The incidence of infections did not differ significantly with vs without ciprofloxacin prophylaxis. The risk of pancreatic cyst infection after EUS-FNA is not

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Increased Hospitalization and Mortality in Patients With COVID-19 and Pre-existing Liver Disease

More than half of patients with COVID-19 have markers of liver injury, researchers report in Gastroenterology. However, patients with pre-existing liver disease, and even more so those with cirrhosis, have increased risks for hospitalizations and death, the study found. Shailendra Singh and Ahmad Khan studied the effects pre-existing liver disease

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  • AGA Clinical Practice Update: Pause IBD Meds For Patients With COVID-19

AGA Clinical Practice Update: Pause IBD Meds For Patients With COVID-19

Patients with inflammatory bowel diseases (IBD) with COVID-19 should delay biological therapies, restarting them once symptoms are gone, says a clinical practice update from the American Gastroenterological Association (AGA). The practice update, written by David T Rubin et al, says that patients with IBD who test positive for SARS-CoV-2 but

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  • Meta-analysis: a Comprehensive Look at Gastrointestinal Effects of COVID-19
  • Meta-analysis: a Comprehensive Look at Gastrointestinal Effects of COVID-19

Meta-analysis: a Comprehensive Look at Gastrointestinal Effects of COVID-19

An analysis of data from the Hong Kong cohort of patients with COVID-19 and a meta-analysis of findings from publications found that 17.6% of patients with COVID-19 had gastrointestinal symptoms. This Gastroenterology study also reports that virus RNA was detected in stool samples from 48.1% patients—even in stool collected after

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  • COVID-19: AGA Practice Updates and Research Article Collection

COVID-19: AGA Practice Updates and Research Article Collection

The American Gastroenterological Association (AGA) has created a special site to keep the gastroenterology and hepatology fields updated on clinical guidance, research findings, and physician resources for COVID-19. The COVID-19 Journal Collection provides links to all the articles on SARS-CoV-2 infection published in the AGA Journals. The latest news includes:

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  • COVID-19 Detected in Gastrointestinal Tract and Feces

COVID-19 Detected in Gastrointestinal Tract and Feces

SARS-CoV-2  (COVID-19) and its receptor are present in the gastrointestinal tract, even after clearance of the virus from respiratory tract, researchers report in Gastroenterology. Infection with COVID-19 causes respiratory illnesses including severe respiratory syndrome (SARS), so it infects respiratory epithelial cells and spreads via respiratory tract. However, the viral target

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  • How Do Diet and Antibiotic Use Affect Risk of Colorectal Tumor Recurrence?

How Do Diet and Antibiotic Use Affect Risk of Colorectal Tumor Recurrence?

Researchers have identified mechanisms by which diet and antibiotic use together promote tumorigenesis by colon cancer cells at the anastomosis after colorectal surgery, reported in the March issue of Gastroenterology. Strategies to prevent emergence of these microbe communities or their enzymatic activities might be used to reduce the risk of

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  • REVIEW: All About Gastric (Stomach) Cancer

REVIEW: All About Gastric (Stomach) Cancer

Despite the worldwide decrease in gastric cancer incidence and mortality over the past 5 decades, it is still the third-leading cause of cancer-related death. Understanding the epidemiology and risk factors for gastric cancer can aide in determination of risk, screening, and prevention. In the March issue of Clinical Gastroenterology and

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What Treatments Are Effective for Chronic Nausea and Vomiting?

Gastric electrical stimulation reduces vomiting in patients with refractory chronic vomiting and/or nausea, researchers report in a randomized trial published in the February issue of Gastroenterology. Chronic nausea and vomiting are estimated to affect 2.2% of the adult population. For many patients, dietary changes and medical treatments do not improve symptoms,

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REVIEW: Transitioning Adolescents With Inflammatory Bowel Diseases to Adult Care

Adolescents and young adults diagnosed with inflammatory bowel diseases (IBDs) in pediatric care are vulnerable during their transition to adult care. A review article in the February issue of Clinical Gastroenterology and Hepatology discusses the transition from pediatric to adult care for IBD, makes recommendations to improve this process, and identifies

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  • AGA Clinical Practice Guideline: Management of Moderate to Severe Ulcerative Colitis

AGA Clinical Practice Guideline: Management of Moderate to Severe Ulcerative Colitis

The AGA’s latest guideline provides recommendations for the management of adult outpatients with moderate to severe ulcerative colitis (UC) and adult hospitalized patients with acute severe UC. The guideline, written by Joseph D. Feuerstein et al, discusses the use of immunomodulators, biologics, and small molecules to induce and maintain remission

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  • Do Different Bariatric Procedures Have Different Effects in Different Patients?

Do Different Bariatric Procedures Have Different Effects in Different Patients?

Different endoscopic and surgical procedures for weight-loss have different effects on gastric emptying that affect weight loss, researchers report in the January issue of Clinical Gastroenterology and Hepatology. Patients should therefore be assessed for gastric emptying of solids before therapy is selected. The study found that patients with rapid gastric

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  • Is Red Wine Consumption Good for Your Intestinal Microbiome?

Is Red Wine Consumption Good for Your Intestinal Microbiome?

Consumption of red wine increases gut health, based on α-diversity of the intestinal microbiome, researchers report in the January 2020 issue of Gastroenterology. White wine had only weak effects, whereas beer, cider, spirits had none. The researchers propose that even infrequent red wine consumption benefits gut health, possibly via effects

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