Gastro’s Top 20 Articles of 2020

Gastro’s Top 20 Articles of 2020

The Gastroenterology Board of Editors has compiled a list of the Top 20 gastroenterology and hepatology articles published, from any journal, in 2020. The list was created based on a survey of Gastroenterology’s diverse, international Board of Editors for their favorite articles of the past year—those that were most influential, novel, and

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Winter Edition of the AGA Clinician’s Companion

Winter Edition of the AGA Clinician’s Companion

The Winter edition of the AGA Clinician’s Companion—the go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to the current edition as well as

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High Prevalence of Fatty Liver Disease Among Adolescents, Measured by Transient Elastography

High Prevalence of Fatty Liver Disease Among Adolescents, Measured by Transient Elastography

The prevalence of metabolic-associated fatty liver disease (MAFLD), detected by transient elastography, is alarmingly high among adolescents, researchers report in the February issue of Clinical Gastroenterology and Hepatology. Effective noninvasive strategies are needed to differentiate simple steatosis from progressive forms are urgently needed. With the increasing prevalence of obesity, MAFLD has

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  • How Does SARS-CoV-2 Binding to ACE2 Alter the Gut to Promote Systemic Inflammation?

How Does SARS-CoV-2 Binding to ACE2 Alter the Gut to Promote Systemic Inflammation?

SARS-CoV-2, by down-regulating intestinal angiotensin converting enzyme 2 (ACE2), alters the intestinal microbiome and promotes leaky gut syndrome, increasing plasma bacterial lipopolysaccharides and/or peptidoglycans to promote systemic inflammation, Josef M. Penninger et al explain in a Brief Review in the January issue of Gastroenterology. Strategies to increase intestinal ACE2 might

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What Treatments Are Effective for EoE in the Real World?

What Treatments Are Effective for EoE in the Real World?

Of available treatments, topical steroids are most effective at inducing clinical and histologic remission in patients with eosinophilic esophagitis (EoE, in about two-thirds of patients), but proton pump inhibitors (PPIs) are the most frequently prescribed, followed by dietary therapies, found an analysis of data from a large cohort of patients

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What Cells Prevent Pancreatic Cancer Progression?

What Cells Prevent Pancreatic Cancer Progression?

Tuft cells inhibit progression of inflammation-induced pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDA), researchers report in the November issue of Gastroenterology. These unique cells were found to suppress tumor progression via secretion of lipid eicosanoid mediators. Tuft cells are solitary chemosensory cells found throughout organs of the respiratory

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Fall Edition of the AGA Clinician’s Companion

Fall Edition of the AGA Clinician’s Companion

The Fall edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to all 4 issues for the

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Internet Searches for GI Symptoms Predict Regional Increases in COVID-19 Cases

Google searches for specific, common gastrointestinal (GI) symptoms correlated with incidence of COVID-19 in the first weeks of the pandemic in 5 states with high disease burden, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Specifically, searches for loss of appetite or taste correlated with increases in COVID-19 cases

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  • Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Patients hospitalized with COVID-19 have alterations in their fecal mycobiomes, including enrichment of fungal pathogens from the genera Candida and Aspergillus, compared with controls researchers report in the October issue of Gastroenterology. Unstable gut mycobiomes and prolonged dysbiosis persisted in a subset of patients with COVID-19 for as long as 12 days after nasopharyngeal

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  • Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Pediatric patients with inflammatory bowel diseases (IBD) have a low risk of severe COVID-19, even when receiving biologic and/or other immune suppressive therapies, researchers report in Clinical Gastroenterology and Hepatology. These findings support recommendations to continue maintenance IBD treatment for pediatric patients throughout the currentpandemic. SARS-CoV2 enters human cells via

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Use of Famotidine Associated With Improved Outcomes of Hospitalized COVID-19 Patients

In patients hospitalized with COVID-19 and not initially intubated, use of famotidine is associated with a 2-fold reduction in clinical deterioration leading to intubation or death, a retrospective study in Gastroenterology showed. Famotidine is a histamine-2 receptor antagonist that suppresses gastric acid production. In vitro, famotidine inhibits HIV replication, and a

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  • Efficacy of 8 Weeks Treatment With Glecaprevir-Pibrentasvir in an Integrated Analysis of Patients With Chronic HCV Infection

Efficacy of 8 Weeks Treatment With Glecaprevir-Pibrentasvir in an Integrated Analysis of Patients With Chronic HCV Infection

Eight weeks treatment with glecaprevir-pibrentasvir was efficacious and well tolerated in treatment-naive patients with all hepatitis C virus (HCV) genotype infections, with or without cirrhosis, researchers report in a pooled analysis of studies in the October issue of Clinical Gastroenterology and Hepatology. In a post-hoc analysis of data from 8

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What IBD Treatments are Associated With Adverse Outcomes in Patients With COVID-19?

Among patients with inflammatory bowels diseases (IBD), older age, increased number of comorbidities, and use of systemic corticosteroids are strong risk factors for adverse outcomes from COVID-19, researchers report in the September issue of Gastroenterology. Maintenance of remission with steroid-sparing treatments is therefore important in management of patients with IBD

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What Drinks Increase Risk of Reflux Symptoms?

Intake of coffee, tea, or soda is associated with an increased risk of gastroesophageal reflux (GER) symptoms, researchers report in the September issue of Clinical Gastroenterology and Hepatology. In contrast, consumption of water, juice, or milk is not associated with GER symptoms. Drinking water instead of coffee, tea, or soda reduces

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