Fall Edition of the AGA Clinician’s Companion

Fall Edition of the AGA Clinician’s Companion

The Fall edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to all 4 issues for the

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Internet Searches for GI Symptoms Predict Regional Increases in COVID-19 Cases

Google searches for specific, common gastrointestinal (GI) symptoms correlated with incidence of COVID-19 in the first weeks of the pandemic in 5 states with high disease burden, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Specifically, searches for loss of appetite or taste correlated with increases in COVID-19 cases

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  • Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Patients hospitalized with COVID-19 have alterations in their fecal mycobiomes, including enrichment of fungal pathogens from the genera Candida and Aspergillus, compared with controls researchers report in the October issue of Gastroenterology. Unstable gut mycobiomes and prolonged dysbiosis persisted in a subset of patients with COVID-19 for as long as 12 days after nasopharyngeal

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  • Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Pediatric patients with inflammatory bowel diseases (IBD) have a low risk of severe COVID-19, even when receiving biologic and/or other immune suppressive therapies, researchers report in Clinical Gastroenterology and Hepatology. These findings support recommendations to continue maintenance IBD treatment for pediatric patients throughout the currentpandemic. SARS-CoV2 enters human cells via

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Use of Famotidine Associated With Improved Outcomes of Hospitalized COVID-19 Patients

In patients hospitalized with COVID-19 and not initially intubated, use of famotidine is associated with a 2-fold reduction in clinical deterioration leading to intubation or death, a retrospective study in Gastroenterology showed. Famotidine is a histamine-2 receptor antagonist that suppresses gastric acid production. In vitro, famotidine inhibits HIV replication, and a

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  • Efficacy of 8 Weeks Treatment With Glecaprevir-Pibrentasvir in an Integrated Analysis of Patients With Chronic HCV Infection

Efficacy of 8 Weeks Treatment With Glecaprevir-Pibrentasvir in an Integrated Analysis of Patients With Chronic HCV Infection

Eight weeks treatment with glecaprevir-pibrentasvir was efficacious and well tolerated in treatment-naive patients with all hepatitis C virus (HCV) genotype infections, with or without cirrhosis, researchers report in a pooled analysis of studies in the October issue of Clinical Gastroenterology and Hepatology. In a post-hoc analysis of data from 8

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What IBD Treatments are Associated With Adverse Outcomes in Patients With COVID-19?

Among patients with inflammatory bowels diseases (IBD), older age, increased number of comorbidities, and use of systemic corticosteroids are strong risk factors for adverse outcomes from COVID-19, researchers report in the September issue of Gastroenterology. Maintenance of remission with steroid-sparing treatments is therefore important in management of patients with IBD

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What Drinks Increase Risk of Reflux Symptoms?

Intake of coffee, tea, or soda is associated with an increased risk of gastroesophageal reflux (GER) symptoms, researchers report in the September issue of Clinical Gastroenterology and Hepatology. In contrast, consumption of water, juice, or milk is not associated with GER symptoms. Drinking water instead of coffee, tea, or soda reduces

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  • What do Endoscopies Find in Patients With COVID-19?

What do Endoscopies Find in Patients With COVID-19?

Endoscopic examinations reveal abnormalities in a high proportion of COVID-19 cases, researchers report in Clinical Gastroenterology and Hepatology. Peptic ulcers and esophagitis were detected in most upper GI endoscopies, and colitis, ranging from mild to more severe ulcerative lesions, was the most common finding during colonoscopy. No endoscopists became infected

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  • Summer Edition of the AGA Clinician’s Companion

Summer Edition of the AGA Clinician’s Companion

The summer edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! This latest edition of the AGA Clinician’s Companion, published online quarterly, summarizes research findings most relevant to clinicians on the risk of

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  • Is Moderate Alcohol Use a Risk Factor for Nonalcoholic Liver Disease?

Is Moderate Alcohol Use a Risk Factor for Nonalcoholic Liver Disease?

Researchers report an association between alcohol use and liver fat—even after heavy users of alcohol were excluded from the analysis. Finding from the study, published in Clinical Gastroenterology and Hepatology, indicate that alcohol use is a risk factor for nonalcoholic fatty liver disease (NAFLD). Many individuals presumed to have NAFLD

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Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Cannabis and its derivatives can have beneficial but also detrimental effects on gastrointestinal and hepatic function, via the endocannabinoid system (ECS). These are discussed in a review article in the July issue of Gastroenterology. Cannabis and its derivatives affect many gastrointestinal processes via the ECS and has reported anti-inflammatory, anti-nociceptive,

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Addition of Nucleic Acid Polymers Improves Outcomes of Patients With HBV Infection

Addition of nucleic acid polymers (NAPs), which inhibit assembly and secretion of hepatitis B virus (HBV) subviral particles, to tenofovir disoproxil fumarate (TDF) and pegIFN therapy significantly increased rates of HBsAg loss and seroconversion, and functional cure, after therapy, researchers report in Gastroenterology. Chronic HBV infection causes progressive liver fibrosis,

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  • Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea is a frequent symptom in patients infected with SARS-CoV-2, researchers report in articles published in Clinical Gastroenterology and Hepatology. Researchers propose suspecting COVID-19 in any patient with diarrhea, even in the absence of respiratory symptoms, and taking appropriate precautions and approaching endoscopy as a procedure with high risk of

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