The Gastroenterology Board of Editors has compiled a list of the Top 20 gastroenterology and hepatology articles published, from any journal, in 2020. The list was created based on a survey of Gastroenterology’s diverse, international Board of Editors for their favorite articles of the past year—those that were most influential, novel, and likely to change practice.
Many of the studies, as might be expected, were of the severe acute respiratory syndrome novel coronavirus-2 (SARS-CoV-2) pandemic and its associated coronavirus disease 2019 (COVID-19). These articles will be assembled in a special issue.
The articles in this Top 20 list covered topics such as the effects of brain–gut interactions on dietary and sugar preferences, gut microbes that translocate to mesenteric adipose to promote formation of creeping fat in patients with Crohn’s disease, and new treatments for liver diseases such as chronic hepatitis B virus (HBV) infection, nonalcoholic steatohepatitis with cirrhosis, and hepatocellular carcinoma.
Other articles covered technicologic advances such as the use of deep learning to detect neoplasia in patients with Barrett’s esophagus, nanoparticles that induce immune tolerance to gliadin in mouse models of celiac disease, and detection of adenomas using computer-aided detection-assisted colonoscopy.
Other articles explored the effects of frailty in patients with inflammatory bowel diseases (IBD) and how much gluten is in so-called gluten-free diets. 2020 was a big year for tuft cells—one article on the list revealed the mechanisms by which tuft cells prevent pancreatic tumorigenesis, while another showed that succinate produced by intestinal microbes promotes specification of tuft cells to suppress ileal inflammation.
There were also new insights into differences in fecal microbiomes and metabolomes of people with vs without irritable bowel syndrome (IBS) and bile acid malabsorption, as well as determination that the NLRP3 inflammasome regulates development of inflammatory and anti-inflammatory response syndromes in mice with acute pancreatitis.
The Top 20 List reflects Gastroenterology’s commitment to translational, cross-disciplinary research and technologic advances to identify mechanisms of GI and liver disease pathogenesis and treatments.