Immunosuppressant therapy causes permanent recovery from liver failure in most children with autoimmune hepatitis (AIH), reports Miriam Cuarterolo et al. in the February issue of Clinical Gastroenterology and Hepatology. AIH is a progressive, inflammatory liver disease that predominantly affects girls before puberty. Without treatment, it progresses to cirrhosis and liver
Read moreResearchers have identified a molecule that protects colon cells from injury in a mouse model of inflammatory bowel disease (IBD). The study, published by Beth McConnell et al. in the February issue of Gastroenterology, reports that Klf5 controls genes that mediate recovery from colonic injury. Klf5 regulates transcription of genes
Read moreDriving privileges of people with hepatic encephalopathy (HE) should be restricted until they demonstrate that they are safe on the road, according to Stanley Martin Cohen et al. in the February issue of Clinical Gastroenterology and Hepatology. Because there are few laws about which patients with HE or other mental
Read moreMutations in the cystic fibrosis transmembrane conductance regulator (CFTR) cause well-known lung defects, but in the January issue of Gastroenterology, Chee Y. Ooi et al. describe specific CFTR genotypes that increase risk for pancreatitis. Most patients with cystic fibrosis that carry mutations that severely disrupt CFTR function have a pancreatic
Read moreThe speed of cyst growth predicts whether branch duct intraductal papillary mucinous neoplasms (Br-IPMNs) will become malignant, according to a study by Mee Joo Kang et al. in the January issue of Clinical Gastroenterology and Hepatology. IPMN is a premalignant pancreatic lesion that progresses from adenoma to carcinoma; cysts are
Read moreResearchers have found a way to specifically kill liver cancer cells and stop tumor growth. In the January issue of Gastroenterology, Guangming Chen et al. report that fusion of a natural inhibitor of telomerase to an HIV protein stops proliferation of hepatocellular carcinoma (HCC) cells and growth of liver tumors
Read moreBaked goods made from fully hydrolyzed wheat flour, manufactured with sourdough lactobacilli and fungal proteases, are safe for patients with celiac disease, according to the January issue of Clinical Gastroenterology and Hepatology. Celiac disease is caused by an inflammatory response to wheat gluten. Luigi Greco et al. gave patients with celiac
Read morePatients with Cowden syndrome (CS) are at high risk for early-onset colorectal cancer, according to the December issue of Gastroenterology. CS is caused by mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN). Patients typically have mucocutaneous lesions, large-sized heads, and increased risk for breast, thyroid, and endometrial
Read moreHIV infection does not speed the progression of fibrosis in patients with Hepatitis C, according to findings from Richard Sterling et al. in the December issue of Clinical Gastroenterology and Hepatology. Sterling et al. compared liver biopsies taken from more than 300 patients with HIV/HCV co-infection and more than 200
Read morePatients with irritable bowel syndrome (IBS) had significant improvements in bowel habits and reductions in abdominal pain after taking a new drug called linaclotide, reports a study published in the December issue of Gastroenterology. Jeffrey M. Johnston et al. performed a placebo-controlled phase 2 trial of 4 different doses of
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Dr. Kristine Novak is the science editor for Gastroenterology and Clinical Gastroenterology and Hepatology. She has worked as an editor at biomedical research journals and as a science writer for 15 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
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