How Does SARS-CoV-2 Binding to ACE2 Alter the Gut to Promote Systemic Inflammation?
SARS-CoV-2, by down-regulating intestinal angiotensin converting enzyme 2 (ACE2), alters the intestinal microbiome and promotes leaky gut syndrome, increasing plasma bacterial lipopolysaccharides and/or peptidoglycans to promote systemic inflammation, Josef M. Penninger et al explain in a Brief Review in the January issue of Gastroenterology. Strategies to increase intestinal ACE2 might
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