Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Cannabis and its derivatives can have beneficial but also detrimental effects on gastrointestinal and hepatic function, via the endocannabinoid system (ECS). These are discussed in a review article in the July issue of Gastroenterology. Cannabis and its derivatives affect many gastrointestinal processes via the ECS and has reported anti-inflammatory, anti-nociceptive,

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Addition of Nucleic Acid Polymers Improves Outcomes of Patients With HBV Infection

Addition of nucleic acid polymers (NAPs), which inhibit assembly and secretion of hepatitis B virus (HBV) subviral particles, to tenofovir disoproxil fumarate (TDF) and pegIFN therapy significantly increased rates of HBsAg loss and seroconversion, and functional cure, after therapy, researchers report in Gastroenterology. Chronic HBV infection causes progressive liver fibrosis,

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  • Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea is a frequent symptom in patients infected with SARS-CoV-2, researchers report in articles published in Clinical Gastroenterology and Hepatology. Researchers propose suspecting COVID-19 in any patient with diarrhea, even in the absence of respiratory symptoms, and taking appropriate precautions and approaching endoscopy as a procedure with high risk of

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Nutritional Risks in Adolescents After Bariatric Surgery

Adolescents undergoing vertical sleeve gastrectomy (VSG) have fewer nutritional deficiencies than Roux-en-Y bypass (RYGB) at 5 years after the procedure, but both can produce deficiencies in iron and B12, researchers report in Clinical Gastroenterology and Hepatology. Ongoing nutrient monitoring and supplementation are recommended for all patients who receive bariatric surgery. 

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Corticosteroids, but not TNF Antagonists, Associate With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases

Increasing age, comorbidities, and use of corticosteroids and other anti-inflammatory agents correlated with severe COVID-19 in patients with inflammatory bowel diseases (IBD), whereas treatment with tumor necrosis factor (TNF) antagonists did not, researchers report in Gastroenterology. Corticosteroids, immunomodulators (thiopurines, methotrexate), and biologic agents (TNF antagonists such as infliximab) are commonly

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Is Antibiotic Prophylaxis Necessary During EUS-FNA of Pancreatic Cystic Lesions?

Risk of infection is low in patients undergoing endoscopic ultrasound with fine-needle aspiration (EUS-FNA) of pancreatic cysts, researchers report from a randomized controlled trial published in Gastroenterology. The incidence of infections did not differ significantly with vs without ciprofloxacin prophylaxis. The risk of pancreatic cyst infection after EUS-FNA is not

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Increased Hospitalization and Mortality in Patients With COVID-19 and Pre-existing Liver Disease

More than half of patients with COVID-19 have markers of liver injury, researchers report in Gastroenterology. However, patients with pre-existing liver disease, and even more so those with cirrhosis, have increased risks for hospitalizations and death, the study found. Shailendra Singh and Ahmad Khan studied the effects pre-existing liver disease

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  • AGA Clinical Practice Update: Pause IBD Meds For Patients With COVID-19

AGA Clinical Practice Update: Pause IBD Meds For Patients With COVID-19

Patients with inflammatory bowel diseases (IBD) with COVID-19 should delay biological therapies, restarting them once symptoms are gone, says a clinical practice update from the American Gastroenterological Association (AGA). The practice update, written by David T Rubin et al, says that patients with IBD who test positive for SARS-CoV-2 but

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  • Meta-analysis: a Comprehensive Look at Gastrointestinal Effects of COVID-19
  • Meta-analysis: a Comprehensive Look at Gastrointestinal Effects of COVID-19

Meta-analysis: a Comprehensive Look at Gastrointestinal Effects of COVID-19

An analysis of data from the Hong Kong cohort of patients with COVID-19 and a meta-analysis of findings from publications found that 17.6% of patients with COVID-19 had gastrointestinal symptoms. This Gastroenterology study also reports that virus RNA was detected in stool samples from 48.1% patients—even in stool collected after

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  • COVID-19: AGA Practice Updates and Research Article Collection

COVID-19: AGA Practice Updates and Research Article Collection

The American Gastroenterological Association (AGA) has created a special site to keep the gastroenterology and hepatology fields updated on clinical guidance, research findings, and physician resources for COVID-19. The COVID-19 Journal Collection provides links to all the articles on SARS-CoV-2 infection published in the AGA Journals. The latest news includes:

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