SARS-CoV-2, by down-regulating intestinal angiotensin converting enzyme 2 (ACE2), alters the intestinal microbiome and promotes leaky gut syndrome, increasing plasma bacterial lipopolysaccharides and/or peptidoglycans to promote systemic inflammation, Josef M. Penninger et al explain in a Brief Review in the January issue of Gastroenterology. Strategies to increase intestinal ACE2 might
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Of available treatments, topical steroids are most effective at inducing clinical and histologic remission in patients with eosinophilic esophagitis (EoE, in about two-thirds of patients), but proton pump inhibitors (PPIs) are the most frequently prescribed, followed by dietary therapies, found an analysis of data from a large cohort of patients
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Tuft cells inhibit progression of inflammation-induced pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDA), researchers report in the November issue of Gastroenterology. These unique cells were found to suppress tumor progression via secretion of lipid eicosanoid mediators. Tuft cells are solitary chemosensory cells found throughout organs of the respiratory
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The Fall edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to all 4 issues for the
Read moreGoogle searches for specific, common gastrointestinal (GI) symptoms correlated with incidence of COVID-19 in the first weeks of the pandemic in 5 states with high disease burden, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Specifically, searches for loss of appetite or taste correlated with increases in COVID-19 cases
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Patients hospitalized with COVID-19 have alterations in their fecal mycobiomes, including enrichment of fungal pathogens from the genera Candida and Aspergillus, compared with controls researchers report in the October issue of Gastroenterology. Unstable gut mycobiomes and prolonged dysbiosis persisted in a subset of patients with COVID-19 for as long as 12 days after nasopharyngeal
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Pediatric patients with inflammatory bowel diseases (IBD) have a low risk of severe COVID-19, even when receiving biologic and/or other immune suppressive therapies, researchers report in Clinical Gastroenterology and Hepatology. These findings support recommendations to continue maintenance IBD treatment for pediatric patients throughout the currentpandemic. SARS-CoV2 enters human cells via
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Eight weeks treatment with glecaprevir-pibrentasvir was efficacious and well tolerated in treatment-naive patients with all hepatitis C virus (HCV) genotype infections, with or without cirrhosis, researchers report in a pooled analysis of studies in the October issue of Clinical Gastroenterology and Hepatology. In a post-hoc analysis of data from 8
Read moreAmong patients with inflammatory bowels diseases (IBD), older age, increased number of comorbidities, and use of systemic corticosteroids are strong risk factors for adverse outcomes from COVID-19, researchers report in the September issue of Gastroenterology. Maintenance of remission with steroid-sparing treatments is therefore important in management of patients with IBD
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Dr. Kristine Novak is the science editor for Gastroenterology and Clinical Gastroenterology and Hepatology. She has worked as an editor at biomedical research journals and as a science writer for 15 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
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