Cancer
  • Finding Circulating Tumor Cells in Patients With Pancreaticobiliary Cancers

Finding Circulating Tumor Cells in Patients With Pancreaticobiliary Cancers

Circulating tumor cells (CTCs) can be isolated from portal venous blood collected during endoscopic ultrasound (EUS) of patients with pancreaticobiliary cancers, researchers report in the December issue of Gastroenterology. CTCs isolated from peripheral blood of patients with metastatic breast, colorectal, or prostate cancer can be analyzed to predict patient survival. However, blood samples from

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  • Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Do Patients Really Prefer Colon Capsule Endoscopy Over Colonoscopy?

Slightly more than 50% of people with an inherited risk for colorectal cancer (CRC) agree to undergo screening for this cancer, and most prefer colonoscopy to colon capsule endoscopy—even though these are equally effective screening tools—researchers report in the December issue of Clinical Gastroenterology and Hepatology. Colonoscopy should therefore remain

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  • Special Issue: Managing Patients With Liver Disease

Special Issue: Managing Patients With Liver Disease

A special issue of Clinical Gastroenterology and Hepatology is dedicated to the clinical management of hepatic disorders, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune hepatitis, and primary sclerosing cholangitis (PSC). The issue comprises 14 review articles that aim to present clinicians with evidence-based guidance and expert opinions on management of patients with liver

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  • Who Should Undergo Surgery for Pancreatic Cysts?

Who Should Undergo Surgery for Pancreatic Cysts?

When should a patient with a pancreatic cystic lesion undergo surgery? How can we tell if the surgery will provide relief, or prevent death from pancreatic cancer, or burden a patient with an unnecessary procedure? Two articles in the October issue of Clinical Gastroenterology and Hepatology increase our understanding of

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  • Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

Special Issue: Genetics, Genetic Testing, and Biomarkers of Digestive Diseases

A special issue of Gastroenterology features 14 articles discussing the genetic factors that contribute to a range of gastrointestinal (GI),  hepatobiliary, and pancreatic diseases, and how this information can be used in diagnosis and treatment of patients. An introduction to the special issue explains the value of associating diseases with specific genetic variants, which can help

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  • What Gene Mutations Cause Familial Colorectal Cancers?

What Gene Mutations Cause Familial Colorectal Cancers?

Mutations in the DNA repair gene, FAN1, cause some inherited forms of colorectal cancer (CRC), researchers report in the September issue of Gastroenterology. Identification of another gene associated with this hereditary cancer will facilitate management of patients with family histories of cancer. Germline mutations in EPCAM, APC, MUTYH, POLE, POLD1, GREM1,

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  • How do Differentiated Tumor Cells Support Cancer Stem Cells?

How do Differentiated Tumor Cells Support Cancer Stem Cells?

Differentiated colorectal cells produce stem cell factor (SCF) to activate KIT signaling in tumor-initiating cells, researchers report in the September issue of Gastroenterology. This pathway maintains the stem-like features of these tumor cells, predominantly under conditions of hypoxia. Colorectal tumors are organized hierarchically and their growth is mediated by an

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  • VEGF Signaling Prevents Senescence in Colorectal Tumors

VEGF Signaling Prevents Senescence in Colorectal Tumors

Vascular endothelial growth factor receptor-2 (VEGFR2) signaling prevents senescence of colorectal cancer cells by inactivating p21, researchers report in the July issue of Gastroenterology. Inactivation of this pathway correlates with survival of patients treated with anti-VEGF cancer drug bevacizumab. VEGF, a growth factor that has been well studied for its

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  • Can Capsule Colonoscopy Accurately Detect Polyps and Adenomas?

Can Capsule Colonoscopy Accurately Detect Polyps and Adenomas?

In an average-risk screening population, capsule colonoscopy identified individuals with polyps and adenomas with high levels of specificity, researchers report in the May issue of Gastroenterology. This procedure might be useful for patients who cannot undergo colonoscopy or who had incomplete colonoscopies. Capsule endoscopy, which involves an ingestible pill-sized endoscope that

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  • What is This Liver Tumor?

What is This Liver Tumor?

Researchers describe a rare liver tumor of vascular origin in the May issue of Clinical Gastroenterology and Hepatology. Laisa Socorro Briongos-Figuero and Tomás Zamora-Martínez describe the case of a 59-year-old man with chronic pancreatitis who was was admitted to the hospital with vomiting and jaundice, without fever or diarrhea. He had a previous history of

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