Cancer
  • How Many Patients are Screened for HBV Infection Before Chemotherapy?

How Many Patients are Screened for HBV Infection Before Chemotherapy?

Only a small percentage of patients receiving chemotherapy are screened for hepatitis B virus (HBV) infection, although the proportion of patients screened has increased slightly over the past decade, researchers report in the May issue of Clinical Gastroenterology and Hepatology. Strategies are needed to ensure that patients receiving chemotherapy are

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  • Special Issue: Food, the Immune System, and the GI Tract

Special Issue: Food, the Immune System, and the GI Tract

The digestion of food and absorption of nutrients is the principal role of the gastrointestinal (GI) tract—everyone wants to know what we should eat and how it affects our body. Interactions between food and the immune system affect our microbiome, development of food allergies, nutrition, risk for inflammatory disorders or cancer, and even

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  • How to Get Rid of H pylori Infection—And do we Need to?

How to Get Rid of H pylori Infection—And do we Need to?

Helicobacter pylori infection increases risk of gastric cancer, by inducing inflammation and genetic instability in the gastric mucosa. However, it is not clear how best to clear the infection, or even whether H pylori can provide some health benefits. In a Review article in the April issue of Gastroenterology, David Y. Graham discusses the mechanisms H pylori–induced carcinogenesis and

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Video Abstract: Increased Risk of Cervical Cancer in Women with IBD

Women with ulcerative colitis or Crohn’s disease are at increased risk for cervical neoplasias, researchers report in the April issue of Clinical Gastroenterology and Hepatology. Christine Rungoe et al performed a population-based cohort study of 27,408 women with inflammatory bowel diseases (IBD). In her video abstract, she says “we observed that women with ulcerative

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  • What is the Best way to Monitor and Manage Dysplasia in Patients with IBD?

What is the Best way to Monitor and Manage Dysplasia in Patients with IBD?

The American Gastroenterological Association, along with the American Society for Gastrointestinal Endoscopy, have issued updated recommendations for the surveillance and management of dysplasia in patients with inflammatory bowel disease (IBD).  In a commentary in the March issue of Gastroenterology, James F. Marion and Bruce E. Sands discuss the recommendations, and how gastroenterologists should best monitor and manage dysplasia

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  • What to do About Sessile Serrated Adenomas

What to do About Sessile Serrated Adenomas

Sessile serrated adenomas (SSAs), characterized by the saw-toothed appearance of the colonic crypts, form and progress to colorectal cancers (CRCs) via a different pathway than conventional adenomas and are thought to contribute to 20% to 35% of all cases of CRC. Although little is known about their pathogenesis, endoscopists must be aware of the unique features of SSAs to efficiently detect

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In Vitro Stomach?

Researchers have developed an advanced, long-term, 3-dimensional organoid culture system for primary, untransformed human gastric epithelium. The system, described in the January issue of Gastroenterology, provides evidence for the presence of stem cells in adult human gastric tissue and can be used to study changes that occur in the gastric epithelium during

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  • Liver Metastases, or Syphilis?

Liver Metastases, or Syphilis?

Researchers report initially mistaking late-stage syphilis for liver metastases in the November issue of Clinical Gastroenterology and Hepatology. Irphan Gaslightwala et al describe a 59-year-old man with a history of chronic lymphocytic leukemia; 6 months of persistent fevers, chills, and night sweats; and loss of 50 pounds. A positron emission tomography–computed tomography

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Video: Use of Full Thickness Resection Device to Remove a Diverticular Polyp

Researchers present a video demonstrating how a full-thickness resection device allows for safe, single-step endoscopic removal and closure of a diverticular adenoma, without leakage of bowel content into the peritoneal cavity. This system, described in the November issue of Gastroenterology, allows for secure resection of high-risk lesions and might even be performed in an outpatient setting.

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  • How Does Smoking Lead to Pancreatic Cancer?

How Does Smoking Lead to Pancreatic Cancer?

Nicotine promotes pancreatic carcinogenesis by disrupting signaling and transcriptional pathways to cause dedifferentiation of acinar cells, researchers report in the November issue of Gastroenterology. One fourth of all deaths from pancreatic ductal adenocarcinoma (PDAC) are associated with tobacco use, and heavy smoking increases risk for PDAC 6-fold. Although smokers develop PDAC

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