GI Tract
Fall Edition of the AGA Clinician’s Companion

Fall Edition of the AGA Clinician’s Companion

The Fall edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to all 4 issues for the

Read more

Internet Searches for GI Symptoms Predict Regional Increases in COVID-19 Cases

Google searches for specific, common gastrointestinal (GI) symptoms correlated with incidence of COVID-19 in the first weeks of the pandemic in 5 states with high disease burden, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Specifically, searches for loss of appetite or taste correlated with increases in COVID-19 cases

Read more
  • Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Patients hospitalized with COVID-19 have alterations in their fecal mycobiomes, including enrichment of fungal pathogens from the genera Candida and Aspergillus, compared with controls researchers report in the October issue of Gastroenterology. Unstable gut mycobiomes and prolonged dysbiosis persisted in a subset of patients with COVID-19 for as long as 12 days after nasopharyngeal

Read more
  • Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Pediatric patients with inflammatory bowel diseases (IBD) have a low risk of severe COVID-19, even when receiving biologic and/or other immune suppressive therapies, researchers report in Clinical Gastroenterology and Hepatology. These findings support recommendations to continue maintenance IBD treatment for pediatric patients throughout the currentpandemic. SARS-CoV2 enters human cells via

Read more

Use of Famotidine Associated With Improved Outcomes of Hospitalized COVID-19 Patients

In patients hospitalized with COVID-19 and not initially intubated, use of famotidine is associated with a 2-fold reduction in clinical deterioration leading to intubation or death, a retrospective study in Gastroenterology showed. Famotidine is a histamine-2 receptor antagonist that suppresses gastric acid production. In vitro, famotidine inhibits HIV replication, and a

Read more
  • What do Endoscopies Find in Patients With COVID-19?

What do Endoscopies Find in Patients With COVID-19?

Endoscopic examinations reveal abnormalities in a high proportion of COVID-19 cases, researchers report in Clinical Gastroenterology and Hepatology. Peptic ulcers and esophagitis were detected in most upper GI endoscopies, and colitis, ranging from mild to more severe ulcerative lesions, was the most common finding during colonoscopy. No endoscopists became infected

Read more
Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Cannabis and its derivatives can have beneficial but also detrimental effects on gastrointestinal and hepatic function, via the endocannabinoid system (ECS). These are discussed in a review article in the July issue of Gastroenterology. Cannabis and its derivatives affect many gastrointestinal processes via the ECS and has reported anti-inflammatory, anti-nociceptive,

Read more
  • Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea is a frequent symptom in patients infected with SARS-CoV-2, researchers report in articles published in Clinical Gastroenterology and Hepatology. Researchers propose suspecting COVID-19 in any patient with diarrhea, even in the absence of respiratory symptoms, and taking appropriate precautions and approaching endoscopy as a procedure with high risk of

Read more

Nutritional Risks in Adolescents After Bariatric Surgery

Adolescents undergoing vertical sleeve gastrectomy (VSG) have fewer nutritional deficiencies than Roux-en-Y bypass (RYGB) at 5 years after the procedure, but both can produce deficiencies in iron and B12, researchers report in Clinical Gastroenterology and Hepatology. Ongoing nutrient monitoring and supplementation are recommended for all patients who receive bariatric surgery. 

Read more

Corticosteroids, but not TNF Antagonists, Associate With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases

Increasing age, comorbidities, and use of corticosteroids and other anti-inflammatory agents correlated with severe COVID-19 in patients with inflammatory bowel diseases (IBD), whereas treatment with tumor necrosis factor (TNF) antagonists did not, researchers report in Gastroenterology. Corticosteroids, immunomodulators (thiopurines, methotrexate), and biologic agents (TNF antagonists such as infliximab) are commonly

Read more