Persons with type 2 diabetes have a more than 2-fold increase in risk for severe liver disease, researchers report in the December issue of Clinical Gastroenterology and Hepatology. The authors found risk factors that might be used to identify persons with type 2 diabetes who should be screened for liver disease.
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Treatment of inflammatory bowel diseases (IBD) with anti-tumor necrosis factor (anti-TNF) drugs restores diversity to the intestinal microbiome, researchers report in the November issue of Gastroenterology. The study associates metabolic interactions among luminal bacteria with outcomes of therapy. Altered interactions between the mucosal immune system and intestinal microbiota contribute to
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Serrated polyps comprise hyperplastic polyps, sessile serrated lesions (SSLs), and traditional serrated adenomas (TSAs). Approximately 25% of sporadic colorectal cancers (CRCs) arise from serrated precursor lesions, but there is confusion regarding their terminology, classification, and risk. A review article by Seth D. Crockett and Iris D. Nagtegaal in the October issue of Gastroenterology clarifies
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Use of phosphodiesterase 5 (PDE5) inhibitors (commonly used to treat erectile dysfunction) is associated with a 35% reduction in risk of colorectal cancer (CRC) among male patients with benign colorectal neoplasms, researchers report in the September issue of Gastroenterology. The decreased risk of CRC was associated with an increased cumulative dose
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In patients who develop dysphagia within a few weeks after fundoplication surgery for gastroesophageal reflux disease (GERD), most symptoms resolve with time and require no intervention. However, patients with clinically significant dysphagia months after this surgery benefit from endoscopic dilation, researchers report in the September issue of Clinical Gastroenterology and
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Mechanisms of Barrett’s esophagus (BE) pathogenesis are discussed in a review article by Jianwen Que et al in the August issue of Gastroenterology, including cell transdifferentiation and transcommitment. The authors discuss potential cells of origin for Barrett’s metaplasia, and the possibility that there could be more than 1 type of BE
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Gastroparesis causes, symptoms, and treatments vary among patients of different races, ethnicities, and sexes, researchers report in the July issue of Clinical Gastroenterology and Hepatology. The prevalence of some gastrointestinal (GI) disorders varies with race and ethnicity. For example, dyspepsia and irritable bowel syndrome are reported less frequently by African Americans.
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Overexpression of the peroxisome proliferator-activated receptor delta (PPARD) in gastric progenitor cells results in inflammation, dysplasia, and tumor formation in mice, researchers report in the July issue of Gastroenterology. Strategies to reduce PPARD in gastric progenitor cells might lead to treatments for stomach cancer. Gastric carcinogenesis is associated with chronic inflammation. The
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Researchers show that you want your endoscopist to be a type-A person — adenoma detect rates (ADRs) are higher among physicians who describe themselves as more compulsive or thorough, researchers report in the July issue of Clinical Gastroenterology and Hepatology. There was no association between ADR and financial incentives, malpractice concerns,
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Dr. Kristine Novak is the science editor for Gastroenterology and Clinical Gastroenterology and Hepatology. She has worked as an editor at biomedical research journals and as a science writer for 15 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
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