Pancreas
Gastro’s Top 20 Articles of 2020

Gastro’s Top 20 Articles of 2020

The Gastroenterology Board of Editors has compiled a list of the Top 20 gastroenterology and hepatology articles published, from any journal, in 2020. The list was created based on a survey of Gastroenterology’s diverse, international Board of Editors for their favorite articles of the past year—those that were most influential, novel, and

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Winter Edition of the AGA Clinician’s Companion

Winter Edition of the AGA Clinician’s Companion

The Winter edition of the AGA Clinician’s Companion—the go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to the current edition as well as

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What Cells Prevent Pancreatic Cancer Progression?

What Cells Prevent Pancreatic Cancer Progression?

Tuft cells inhibit progression of inflammation-induced pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma (PDA), researchers report in the November issue of Gastroenterology. These unique cells were found to suppress tumor progression via secretion of lipid eicosanoid mediators. Tuft cells are solitary chemosensory cells found throughout organs of the respiratory

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Fall Edition of the AGA Clinician’s Companion

Fall Edition of the AGA Clinician’s Companion

The Fall edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! The Clinician’s Companion summarizes high-impact findings recently published in the AGA journals Gastroenterology and Clinical Gastroenterology and Hepatology (CGH). An annual subscription provides access to all 4 issues for the

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  • What are the Risk Factors for Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes?

What are the Risk Factors for Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes?

Persons with type 2 diabetes have a more than 2-fold increase in risk for severe liver disease, researchers report in the December issue of Clinical Gastroenterology and Hepatology. The authors found risk factors that might be used to identify persons with type 2 diabetes who should be screened for liver disease.

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  • How Should We Treat Recurrent Acute Pancreatitis?

How Should We Treat Recurrent Acute Pancreatitis?

Recurrent acute pancreatitis with a clear cause can be treated with endoscopy, explain Liam Zakko and Timothy B. Gardner in a “Here and Now: Clinical Practice” article in the October issue of Clinical Gastroenterology and Hepatology. Acute pancreatitis affects 40 to 50 of every 100,000 Americans per year and is the

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  • Are There Early Signs of Pancreatic Cancer?

Are There Early Signs of Pancreatic Cancer?

Changes in blood glucose and lipid levels occur up to 18 months before a diagnosis of pancreatic cancer, researchers report in the May issue of Gastroenterology. These changes might be used in combination with other risk factors to detect pancreatic cancer at earlier stages. One reason for the high mortality

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  • REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

REVIEW: Combining CRISPR-Cas9 and Organoid Technologies to Study Gastrointestinal Diseases

CRISPR-Cas9 technology can be used to engineer organoids for studies of gastrointestinal development and disease pathogenesis. In the February issue of Gastroenterology, Masayuki Fujii et al review derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 has advanced studies of the digestive system. CRISPR-Cas9 genome editing technology allows researchers to

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  • How Does Cigarette Smoke Promote Pancreatic Tumor Development?

How Does Cigarette Smoke Promote Pancreatic Tumor Development?

Exposure to cigarette smoke activates stem cell features in pancreatic cells, via nicotinic cholinergic receptor signaling to transcription factors that activate expression of stem cell genes, researchers report in the September issue of Gastroenterology. Levels of the stem cell transcriptional regulator PAF1 are increased in pancreatic tumors from humans and

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  • Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Hyperglycemia as a Marker for Early Detection of Pancreatic Cancer

Patients are hyperglycemic for a mean period of 36 to 30 months before a diagnosis of pancreatic ductal adenocarcinoma (PDAC), researchers report in the August issue of Gastroenterology. This information might be used in strategies for early detection. At the time of PDAC diagnosis, approximately 85% of subjects have hyperglycemia

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