• Measuring MicroRNAs to Detect Pancreatic Cancer

Measuring MicroRNAs to Detect Pancreatic Cancer

Analysis of microRNAs improves cytologic analysis of pancreatic fine-needle aspirates, allowing for more accurate identification of patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the October issue of Clinical Gastroenterology and Hepatology. This improvement could reduce the number of diagnostic procedures required for patients with pancreatic masses. Endoscopic ultrasound–guided fine-needle

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  • Can we Increase Detection of Duct Abnormalities by MRCP?

Can we Increase Detection of Duct Abnormalities by MRCP?

Administration of secretin improves noninvasive imaging of pancreatic duct abnormalities with higher levels of sensitivity than magnetic resonance cholangiopancreatography (MRCP), researchers report in the September issue of Gastroenterology. Pancreatic imaging is an essential element in evaluation of patients with abdominal pain or suspected pancreatitis. MRCP allows physicians to visualize fluid

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  • Can a Vaccine Prevent Pancreatic Cancer Progression?

Can a Vaccine Prevent Pancreatic Cancer Progression?

Researchers have developed immunotherapy to slow progression of early-stage pancreatic tumors in mice. This approach might be developed to prevent progression of premalignant lesions to PDA, researchers report in the June issue of Gastroenterology. Pancreatic ductal adenocarcinoma (PDA) is a difficult cancer to treat because it is usually detected at

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  • Cancer Cells in Circulation

Cancer Cells in Circulation

Pancreatic cancer cells can be detected in patients’ circulation before tumors are discovered, researchers report in the March issue of Gastroenterology. Cancer cells have long been believed to acquire metastatic potential after large primary tumors are established. However, many patients undergoing pancreatectomy for chronic pancreatitis are found to have disseminated pancreatic

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Is There a Way to Prevent Pancreatitis After ERCP?

Aggressive intravenous hydration with lactated Ringer’s solution reduces the incidence of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP), but is not associated with volume overload, according to a pilot study published in the February issue of Clinical Gastroenterology and Hepatology. Pancreatitis is the leading complication of ERCP, causing considerable morbidity and

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  • Most Popular Gastroenterology and CGH Papers from 2013

Most Popular Gastroenterology and CGH Papers from 2013

As we begin 2014, we can’t help but look back at 2013 and all the incredible discoveries that were made by gastroenterology and hepatology researchers. Based on the year’s most-downloaded original research articles from Gastroenterology and CGH, exciting things are happening in research on inflammatory bowel diseases, gluten sensitivity, and

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How Does a High-Fat Diet Contribute to Pancreatic Cancer?

A high-fat diet can promote development of pancreatic cancer, but cyclooxygenase-2 (COX2) inhibitors prevent this process, according to a mouse study published in the December issue of Gastroenterology. The mechanisms appear to involve activation of oncogenic KRAS and upregulation of COX2, which promotes pancreatic inflammation. Increased body mass index and

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A New Way to Detect Pancreatic Tumors?

Researchers have developed an ultrasound technique to image pancreatic tumors in mice, described in the October issue of Gastroenterology. This approach might useful in early detection of pancreatic ductal adenocarcinoma (PDAC). PDAC is the fourth leading cause of cancer death in the United States. It is usually diagnosed at an

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A New Drug for Diabetes and Fatty Liver Disease?

Obeticholic acid (OCA)—an agonist of the farnesoid X receptor (FXR)— increases insulin sensitivity and reduces markers of liver inflammation and fibrosis in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), according to a study published in the September issue of Gastroenterology. Type 2 diabetes mellitus and

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How Can We Screen for Pancreatic Cancer and its Precursors?

Individuals with invasive pancreatic cancer or high-grade dysplasia can be identified based on a specific DNA mutation in pancreatic juice samples from the duodena, according to the June issue of Clinical Gastroenterology and Hepatology. Tests for mutant TP53 might be developed to improve the diagnosis of and screening for pancreatic cancer and its precursors.

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