Technology

What are the Barriers to CRC Screening?

Waiving copayments for colonoscopy examinations to detect colorectal cancer (CRC) increases the number of patients that undergo screening, according to a study published in the July issue of Clinical Gastroenterology and Hepatology. Colonoscopy is a recommended, cost-effective method of CRC screening that appears to reduce mortality, yet only half of

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Which Therapy for Helicobacter pylori Infection?

A combination of esomeprazole and 3 antimicrobial agents is less expensive and complex, and equally or more effective, than sequential regimens for eradication of  Helicobacter pylori infection, according to the July issue of Gastroenterology. H pylori infection causes stomach cancer in 20% of infected subjects, so it is important to eliminate. Although

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Surgery, Endocopy, or Medicine for Chronic Pancreatitis?

Endoscopic therapy can be the best initial approach for patients with chronic pancreatitis, according to the July issue of Clinical Gastroenterology and Hepatology. Chronic pancreatitis is a progressive inflammatory disease characterized by abdominal pain and damage to endocrine and exocrine pancreatic tissue. Much of the pain results from intraductal hypertension, caused

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It’s Not Easy to Diagnose Intermediate-Stage Liver Fibrosis

Biopsy has a low level of diagnostic performance for liver fibrosis stages F2 and F1. The recommendation for biopsy analysis, instead of non-invasive tests, for diagnosis of intermediate stages of fibrosis is therefore misleading, according to the June issue of Clinical Gastroenterology and Hepatology. Noninvasive tests such as FibroTest are

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How Does Aspirin Prevent Cancer?

Aspirin blocks proliferation of colorectal cancer cells and causes them to self destruct by inhibiting the mechanistic target of rapamycin (mTOR), according to the June issue of Gastroenterology. Aspirin is a nonsteroidal anti-inflammatory drug that has been shown in many studies to reduce risk of cancer—particularly of CRC—by unknown mechanisms.

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Many Patients Without GERD Continue to Take PPIs

More than 42% of patients with negative results from pH monitoring studies continue proton pump inhibitor (PPI) therapy, despite evidence that they do not have gastroesophageal reflux disease (GERD), according to the June issue of Clinical Gastroenterology and Hepatology. PPI therapy is effective for about 75% of patients with GERD

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Who Will Develop Pouchitis After Ileal Pouch–Anal Anastomosis?

Serum markers can be used to identify patients with ulcerative colitis most likely to have inflammatory complications after ileal pouch–anal anastomosis (IPAA), according to the May issue of Clinical Gastroenterology and Hepatology. More than 20% of individuals with ulcerative colitis eventually need surgery for this disease. Patients with fulminant or

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A Special Issue on Viral Hepatitis

The May issue of Gastroenterology features a very special supplement—“Viral Hepatitis: A Changing Field”—comprising 17 review and commentary articles from international leaders in hepatitis treatment and research. The issue provides insight into the rapid progress made in the treatment and management of patients with viral hepatitis, as well as our

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Is Cardiac Surgery Safe for Patients With Cirrhosis?

Patients with compensated cirrhosis who undergo cardiac surgery with cardiopulmonary bypass do not have greater post-operative mortality or morbidity than other patients who receive this surgery, according to the May issue of Clinical Gastroenterology and Hepatology. Advanced liver disease is a significant risk factor for complications after cardiac surgery, but

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A Better Way to Make Pluripotent Cells From Liver Cells

Researchers have identified an efficient method for creating pluripotent stem cells from differentiated liver cells, according to the April issue of Gastroenterology. This technology could lead to new methods for therapeutic regeneration of diseased or damaged tissues. Embryonic stem cells are pluripotent, in that they can form the 3 germ

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