Lusutrombopag, an oral small molecule agonist of the thrombopoietin receptor, achieves and maintains target platelet count in patients with chronic liver disease and thrombocytopenia undergoing invasive procedures, researchers report in a phase 3, placebo-controlled trial published in the May issue of Clinical Gastroenterology and Hepatology. The drug caused no significant
Read moreAn endoscopic transluminal approach for treatment of infected necrotizing pancreatitis, compared with minimally invasive surgery, significantly reduced major complications, lowered costs, and increased quality of life, according to a randomized trial published in the March issue of Gastroenterology. Acute pancreatitis is the third most common gastrointestinal disorder in the United
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CRISPR-Cas9 technology can be used to engineer organoids for studies of gastrointestinal development and disease pathogenesis. In the February issue of Gastroenterology, Masayuki Fujii et al review derivation of organoids from human gastrointestinal tissues and how CRISPR-Cas9 has advanced studies of the digestive system. CRISPR-Cas9 genome editing technology allows researchers to
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A monoclonal antibody against IL13 reduced histologic and endoscopic features of eosinophilic esophagitis (EoE) in a placebo-controlled phase 2 trial, researchers report in the February issue of Gastroenterology. The antibody, called RPC4046, was well tolerated. EoE is a chronic, immune-mediated disease of the esophagus characterized by eosinophil-mediated mucosal inflammation and
Read moreLower proportions of patients with T1am2/m3 or T1b early-stage esophageal squamous cell carcinomas (EESCCs) treated with endoscopic submucosal dissection (ESD) have perioperative adverse events or disease-specific death after a median follow-up time of 21 months, researchers report in the January issue of Clinical Gastroenterology and Hepatology. The authors found no difference
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An efficient method for cloning gastrointestinal stem cells from biopsies collected during endoscopy is reported in the January isssue of Gastroenterology. A system is needed to isolate, clone, and examine the mucosal stem cells away from confounding effects of immune, stromal, and microbe cells. Markers of stem cells such as
Read moreHuman monoclonal antibodies able to neutralize live human norovirus GII.4 Sydney 2012—the predominant strain responsible for recent outbreaks—are reported in the December issue of Gastroenterology. Researchers analyzed these antibodies and identified the neutralizing epitopes, providing insight into the human immune response to this deadly virus. Human noroviruses are the major
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Endoscopic techniques have been approved by the FDA for management of obesity, with many new devices and technologies in development. The pros and cons of these approaches, and the questions to be answered, are covered in a review article by Andrew C. Storm et al in the November issue of Clinical
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In an analysis of intestinal tissues from patients with Crohn’s disease (CD), researchers identified specific changes in gene expression patterns that associate with histologic changes, such as differences in microvilli length. Decreased microvilli length, via decreased expression of the microvilli gene set, might contribute to epithelial malfunction and the chronic
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This week the AGA Journals Blog has reached an important milestone — its 500th post! The blog was started in 2010 to help disseminate the important discoveries published in the AGA Journals to a broader audience. Eight years and over 132,000 views later, it has updated its readers on everything from biomarkers for colon
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Dr. Kristine Novak has worked as an editor at biomedical research journals and as a science writer for over 15 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
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