Technology
  • Which Patients with Early-stage Ulcerative Colitis Have the Worst Prognoses?

Which Patients with Early-stage Ulcerative Colitis Have the Worst Prognoses?

It is a challenge to accurately identify patients with early-stage ulcerative colitis (UC) who are at highest risk for a poor outcome and therefore might require salvage therapy. In a Perspective article in the April issue of Clinical Gastroenterology and Hepatology, Walter Reinisch et al present prognostic factors for adults with newly

Read more
  • What is the Best way to Monitor and Manage Dysplasia in Patients with IBD?

What is the Best way to Monitor and Manage Dysplasia in Patients with IBD?

The American Gastroenterological Association, along with the American Society for Gastrointestinal Endoscopy, have issued updated recommendations for the surveillance and management of dysplasia in patients with inflammatory bowel disease (IBD).  In a commentary in the March issue of Gastroenterology, James F. Marion and Bruce E. Sands discuss the recommendations, and how gastroenterologists should best monitor and manage dysplasia

Read more
  • Are CMS Payments Associated with Numbers of Medicare Beneficiaries in Each State?

Are CMS Payments Associated with Numbers of Medicare Beneficiaries in Each State?

Medicare and Medicaid Service payments vary greatly across the US, but are not associated with the volume of Medicare beneficiaries or overall per-capita health care costs for each state, researchers report in the March issue of Clinical Gastroenterology and Hepatology. There are large geographic disparities in costs of health care, including costs of

Read more
  • Restoring Immune Regulation to Patients With Alcoholic Hepatitis

Restoring Immune Regulation to Patients With Alcoholic Hepatitis

Patients with alcoholic hepatitis have dysfunctional T-cell and natural killer cell responses that lead to overwhelming bacterial infections. Researchers report in the March issue of Gastroenterology that the immune impairment is mediated by endotoxin-induced over-expression of proteins called programmed cell death 1 (PD1) and mucin domain–containing protein 3 (TIM3), which suppress the immune

Read more

In Vitro Stomach?

Researchers have developed an advanced, long-term, 3-dimensional organoid culture system for primary, untransformed human gastric epithelium. The system, described in the January issue of Gastroenterology, provides evidence for the presence of stem cells in adult human gastric tissue and can be used to study changes that occur in the gastric epithelium during

Read more
  • Is There a Treatment for Rumination Syndrome?

Is There a Treatment for Rumination Syndrome?

Rumination is an unperceived somatic response to food ingestion that disrupts abdominal accommodation, researchers report in the January issue of Clinical Gastroenterology and Hepatology. They go on to show that it can be corrected by biofeedback-guided control of abdomino-thoracic muscular activity. Rumination syndrome is characterized by effortless recurrent regurgitation of

Read more
  • Probiotics for Cirrhosis?

Probiotics for Cirrhosis?

A probiotic solution significantly reduced the risk of hospitalization for hepatic encephalopathy and markers of liver disease severity in patients with cirrhosis, researchers report in the December issue of Gastroenterology. Hepatic encephalopathy develops in 50%–70% of patients with cirrhosis; fewer than 50% of these patients survive for 1 year. Rifaximin and

Read more
  • Microbes go With the Flow (of Oxygen) in the Intestine

Microbes go With the Flow (of Oxygen) in the Intestine

The intestine contains a radial gradient of microbes that changes with the distribution of oxygen and nutrients, researchers report in the November issue of Gastroenterology. Further study of this distribution could provide information about activities of the microbiota in the healthy and inflamed intestine. The bacteria of the intestinal live in

Read more

Video: Use of Full Thickness Resection Device to Remove a Diverticular Polyp

Researchers present a video demonstrating how a full-thickness resection device allows for safe, single-step endoscopic removal and closure of a diverticular adenoma, without leakage of bowel content into the peritoneal cavity. This system, described in the November issue of Gastroenterology, allows for secure resection of high-risk lesions and might even be performed in an outpatient setting.

Read more
  • Using High-resolution Microendoscopy to Detect Gastrointestinal Neoplasia

Using High-resolution Microendoscopy to Detect Gastrointestinal Neoplasia

The high-resolution microendoscope (HRME) allows for real-time imaging of the esophageal and gastric epithelium with subcellular resolution. In an Advances in Translational Science article in the November issue of Clinical Gastroenterology and Hepatology, Justin S. Louie et al discuss the performance of this portable, low cost, optical biopsy technology in screening and surveillance of gastrointestinal

Read more