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  • How Does SARS-CoV-2 Binding to ACE2 Alter the Gut to Promote Systemic Inflammation?

How Does SARS-CoV-2 Binding to ACE2 Alter the Gut to Promote Systemic Inflammation?

SARS-CoV-2, by down-regulating intestinal angiotensin converting enzyme 2 (ACE2), alters the intestinal microbiome and promotes leaky gut syndrome, increasing plasma bacterial lipopolysaccharides and/or peptidoglycans to promote systemic inflammation, Josef M. Penninger et al explain in a Brief Review in the January issue of Gastroenterology. Strategies to increase intestinal ACE2 might

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What Treatments Are Effective for EoE in the Real World?

What Treatments Are Effective for EoE in the Real World?

Of available treatments, topical steroids are most effective at inducing clinical and histologic remission in patients with eosinophilic esophagitis (EoE, in about two-thirds of patients), but proton pump inhibitors (PPIs) are the most frequently prescribed, followed by dietary therapies, found an analysis of data from a large cohort of patients

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What IBD Treatments are Associated With Adverse Outcomes in Patients With COVID-19?

Among patients with inflammatory bowels diseases (IBD), older age, increased number of comorbidities, and use of systemic corticosteroids are strong risk factors for adverse outcomes from COVID-19, researchers report in the September issue of Gastroenterology. Maintenance of remission with steroid-sparing treatments is therefore important in management of patients with IBD

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What Drinks Increase Risk of Reflux Symptoms?

Intake of coffee, tea, or soda is associated with an increased risk of gastroesophageal reflux (GER) symptoms, researchers report in the September issue of Clinical Gastroenterology and Hepatology. In contrast, consumption of water, juice, or milk is not associated with GER symptoms. Drinking water instead of coffee, tea, or soda reduces

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  • Summer Edition of the AGA Clinician’s Companion

Summer Edition of the AGA Clinician’s Companion

The summer edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! This latest edition of the AGA Clinician’s Companion, published online quarterly, summarizes research findings most relevant to clinicians on the risk of

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  • Is Moderate Alcohol Use a Risk Factor for Nonalcoholic Liver Disease?

Is Moderate Alcohol Use a Risk Factor for Nonalcoholic Liver Disease?

Researchers report an association between alcohol use and liver fat—even after heavy users of alcohol were excluded from the analysis. Finding from the study, published in Clinical Gastroenterology and Hepatology, indicate that alcohol use is a risk factor for nonalcoholic fatty liver disease (NAFLD). Many individuals presumed to have NAFLD

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Addition of Nucleic Acid Polymers Improves Outcomes of Patients With HBV Infection

Addition of nucleic acid polymers (NAPs), which inhibit assembly and secretion of hepatitis B virus (HBV) subviral particles, to tenofovir disoproxil fumarate (TDF) and pegIFN therapy significantly increased rates of HBsAg loss and seroconversion, and functional cure, after therapy, researchers report in Gastroenterology. Chronic HBV infection causes progressive liver fibrosis,

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  • Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea and Other Gastroenterologic Effects of COVID-19

Diarrhea is a frequent symptom in patients infected with SARS-CoV-2, researchers report in articles published in Clinical Gastroenterology and Hepatology. Researchers propose suspecting COVID-19 in any patient with diarrhea, even in the absence of respiratory symptoms, and taking appropriate precautions and approaching endoscopy as a procedure with high risk of

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  • COVID-19 Detected in Gastrointestinal Tract and Feces

COVID-19 Detected in Gastrointestinal Tract and Feces

SARS-CoV-2  (COVID-19) and its receptor are present in the gastrointestinal tract, even after clearance of the virus from respiratory tract, researchers report in Gastroenterology. Infection with COVID-19 causes respiratory illnesses including severe respiratory syndrome (SARS), so it infects respiratory epithelial cells and spreads via respiratory tract. However, the viral target

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  • Time for Peer Review Week!

Time for Peer Review Week!

September 19th to 25th is Peer Review Week! Peer Review Week is a global event celebrating the essential role that peer review has in maintaining scientific quality. The goal is to bring together individuals, institutions, and organizations committed to sharing the central message that good peer review, whatever shape or form it

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