• What Causes Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome?

What Causes Visceral Hypersensitivity in Patients with Irritable Bowel Syndrome?

Colon tissues from patients with irritable bowel syndrome (IBS) produce increased levels of specific polyunsaturated fatty acid (PUFA) metabolites, which stimulate sensory neurons to generate visceral hypersensitivity. This occurs via activation of transient receptor potential (TRP) cation channels, researchers show in the August issue of Gastroenterology. IBS is characterized by abdominal

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Bone Tumors, Abdominal Pain, and Aspirin

Physicians report an unusual case of a man with abdominal pain that responded to aspirin therapy, in the October issue of Gastroenterology. It turns out that the pain was caused by a prostaglandin-producing benign bone tumor. Harpal S. Dhaliwal et al. describe examination of a 33-year-old man with an 18-month history

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  • Can Mesalamine Prevent Diverticulitis Recurrence?

Can Mesalamine Prevent Diverticulitis Recurrence?

Mesalamine is no better than placebo in preventing recurrent diverticulitis, and is not recommended for its treatment, researchers conclude from 2 international phase 3 studies. The findings are published in the October issue of Gastroenterology. Diverticular disease is characterized by formation of small pouches (diverticula) that push outward through weak spots in the colon wall.  Diverticulitis

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  • What is the Cause of this Mechanic’s Abdominal Pain?

What is the Cause of this Mechanic’s Abdominal Pain?

A 56-year-old male auto mechanic experienced fever, chills, drenching night sweats, malaise, nausea, and abdominal pain and distention for 6 weeks, associated with 15 kg of lost weight. Twenty years ago he was diagnosed with ileocolonic Crohn’s disease, but he had been asymptomatic on mercaptopurine therapy for the past 10 years. He stopped smoking

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  • What are Choledochoceles?

What are Choledochoceles?

Choledochoceles are cystic dilatations of the intraduodenal portion of the common bile duct. They are often classified as Type III biliary cysts, but have distinct demographic and anatomic features, and a lower risk of malignancy than other types of choledochal cysts. In the February issue of Clinical Gastroenterology and Hepatology,

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  • Is Gluten the Culprit in Non-Celiac Gluten Sensitivity?

Is Gluten the Culprit in Non-Celiac Gluten Sensitivity?

Rapidly fermented poorly absorbed short-chain carbohydrates, rather than gluten or other wheat proteins, might cause gastrointestinal symptoms in people who do not have celiac disease but feel better on gluten-free diets, according to the August issue of Gastroenterology. Individuals with non-celiac gluten sensitivity (NCGS), do not have celiac disease (based on

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Could Differences in Gut Bacteria Cause IBS?

The bacteria that reside in the intestines of adults and children with irritable bowel syndrome (IBS) differ from those of healthy adults and children, according to 2 studies in the November issue of Gastroenterology. Microorganisms account for 90% of the cells in our body (many cannot even be cultured); only

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