• How Do Diet and Antibiotic Use Affect Risk of Colorectal Tumor Recurrence?

How Do Diet and Antibiotic Use Affect Risk of Colorectal Tumor Recurrence?

Researchers have identified mechanisms by which diet and antibiotic use together promote tumorigenesis by colon cancer cells at the anastomosis after colorectal surgery, reported in the March issue of Gastroenterology. Strategies to prevent emergence of these microbe communities or their enzymatic activities might be used to reduce the risk of

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  • Is Red Wine Consumption Good for Your Intestinal Microbiome?

Is Red Wine Consumption Good for Your Intestinal Microbiome?

Consumption of red wine increases gut health, based on α-diversity of the intestinal microbiome, researchers report in the January 2020 issue of Gastroenterology. White wine had only weak effects, whereas beer, cider, spirits had none. The researchers propose that even infrequent red wine consumption benefits gut health, possibly via effects

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  • How Is The Intestinal Microbiome Altered in Patients With IBD and Does it Change During Therapy?

How Is The Intestinal Microbiome Altered in Patients With IBD and Does it Change During Therapy?

Treatment of inflammatory bowel diseases (IBD) with anti-tumor necrosis factor (anti-TNF) drugs restores diversity to the intestinal microbiome, researchers report in the November issue of Gastroenterology.  The study associates metabolic interactions among luminal bacteria with outcomes of therapy. Altered interactions between the mucosal immune system and intestinal microbiota contribute to

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  • A Case of Spirochetosis That Resembles IBD

A Case of Spirochetosis That Resembles IBD

Researchers describe a patient with intestinal spirochetosis—a rare intestinal infection caused by Brachyspira aalborgi or Brachyspira pilosicoli that can involve the colon or terminal ileum and mimic inflammatory bowel diseases—in the May issue of Clinical Gastroenterology and Hepatology. Manasi Agrawal et al report the case of a 45-year-old man with HIV infection and an undetectable viral

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  • Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

Can a Food-based Diet Replace Exclusive Enteral Nutrition for Patients With Crohn’s Disease?

An individualized, food-based diet with similar composition of nutrients to exclusive enteral nutrition (EEN), causes similar changes in the microbiomes of patients with Crohn’s disease (CD), reduces gut inflammation, and is preferred by patients, researchers report in the April issue of Gastroenterology. Non-medical treatments are needed for patients with CD. Diet

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  • What is in Transplanted Fecal Microbiota That Cures Clostridium difficile Infection?

What is in Transplanted Fecal Microbiota That Cures Clostridium difficile Infection?

Researchers have identified a microbiota metabolite that is depleted by the antibiotic clindamycin and replaced with fecal microbiota transplantation (FMT), mediating its effects on recurrent Clostridioides difficile (Clostridium difficile) infection (CDI). Reporting in the November issue of Gastroenterology, the researchers propose that this bacterial metabolite, valerate, might be used in safer and

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  • Does Colony Stimulating Factor Increase Survival of Patients with Alcoholic Hepatitis?

Does Colony Stimulating Factor Increase Survival of Patients with Alcoholic Hepatitis?

In a pilot study from the October issue of Clinical Gastroenterology and Hepatology, colony stimulating factor 3 (CSF3, also called GCSF) improved liver function and increased survival times in patients with severe alcohol-associated hepatitis (AH), compared with standard therapy. Addition of N-acetyl cysteine (NAC) to GCSF did not improve patient outcomes. Patients

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  • Intestinal Microbes as Carcinogens

Intestinal Microbes as Carcinogens

Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.

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  • Does Enhanced Sterilization of Duodenoscopes Reduce Contamination?

Does Enhanced Sterilization of Duodenoscopes Reduce Contamination?

A comparison of duodenoscopes reprocessed by standard high-level disinfection (sHLD) vs double high-level disinfection (dHLD) and standard high-level disinfection followed by ethylene oxide gas sterilization (HLD–ETO) found no significant differences in contamination with multidrug-resistant organisms (MRDO) or other bacteria. The article, published in the October issue of Gastroenterology, concludes that enhanced disinfection

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  • Could the Microbiota Link Metabolic Syndrome With Inflammation?

Could the Microbiota Link Metabolic Syndrome With Inflammation?

Bacterial encroachment—shrinking of the bug-free zone adjacent to the colonic epithelium—is a feature of metabolic syndrome, researchers report in the September issue of Cellular and Molecular Gastroenterology and Hepatology. The findings could explain the relationship between diabetes and inflammation. Mucoid structures that coat the epithelium keep the intestinal microbiota at

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