Corticosteroids, but not TNF Antagonists, Associate With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases

Increasing age, comorbidities, and use of corticosteroids and other anti-inflammatory agents correlated with severe COVID-19 in patients with inflammatory bowel diseases (IBD), whereas treatment with tumor necrosis factor (TNF) antagonists did not, researchers report in Gastroenterology. Corticosteroids, immunomodulators (thiopurines, methotrexate), and biologic agents (TNF antagonists such as infliximab) are commonly

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  • Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Video: Risk of Upper Gastrointestinal Bleeding From Different Drug Combinations

Combined use of nonselective nonsteroidal anti-inflammatory drugs (nNSAIDs), COX-2 selective inhibitors, or low-dose aspirin with selective serotonin reuptake inhibitors significantly increases the risk of upper gastrointestinal (GI) bleeding, researchers report in the October issue of Gastroenterology. In their case series analysis of data from 114,835 patients with upper GI bleeding (930,888 person-years of follow-up),

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What is the Best Treatment for Microscopic Colitis?

The corticosteroid budesonide is the most effective treatment for patients with microscopic colitis (MC), according to a meta-analysis in the October issue of Clinical Gastroenterology and Hepatology. However, once patients stop taking this drug, the rate of symptom relapse is high. MC is an inflammatory disorder of the colon that

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