Chronic infection with the hepatitis C virus (HCV) causes epigenetic changes in liver cells that alter gene expression patterns and continue to affect risk for hepatocellular carcinoma (HCC), regardless of patients’ response to direct-activating antiviral (DAA) agents, researchers report in the June issue of Gastroenterology. These alterations might be targeted
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Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.
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A review article in the March issue of Gastroenterology discusses different hypotheses about the cells responsible for liver tumorigenesis. The article also reviews the different classes of liver tumors, based on the molecular features, and how these affect patient prognosis. Daniela Sia et al describe the distinct molecular and clinical features of hepatocellular
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Nicotine promotes pancreatic carcinogenesis by disrupting signaling and transcriptional pathways to cause dedifferentiation of acinar cells, researchers report in the November issue of Gastroenterology. One fourth of all deaths from pancreatic ductal adenocarcinoma (PDAC) are associated with tobacco use, and heavy smoking increases risk for PDAC 6-fold. Although smokers develop PDAC
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Dr. Kristine Novak is the science editor for Gastroenterology and Clinical Gastroenterology and Hepatology. She has worked as an editor at biomedical research journals and as a science writer for 15 years, covering advances in gastroenterology, hepatology, cancer, immunology, biotechnology, molecular genetics, and clinical trials. She has a PhD in cell biology and an interest in all areas of medical research.
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