Colorectal Cancer in Cowden Syndrome

Patients with Cowden syndrome (CS) are at high risk for early-onset colorectal cancer, according to the December issue of Gastroenterology. CS is caused by mutations in the tumor suppressor gene phosphatase and tensin homolog (PTEN). Patients typically have mucocutaneous lesions, large-sized heads, and increased risk for breast, thyroid, and endometrial

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