• Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Pediatric patients with inflammatory bowel diseases (IBD) have a low risk of severe COVID-19, even when receiving biologic and/or other immune suppressive therapies, researchers report in Clinical Gastroenterology and Hepatology. These findings support recommendations to continue maintenance IBD treatment for pediatric patients throughout the currentpandemic. SARS-CoV2 enters human cells via

Read more
  • What do Endoscopies Find in Patients With COVID-19?

What do Endoscopies Find in Patients With COVID-19?

Endoscopic examinations reveal abnormalities in a high proportion of COVID-19 cases, researchers report in Clinical Gastroenterology and Hepatology. Peptic ulcers and esophagitis were detected in most upper GI endoscopies, and colitis, ranging from mild to more severe ulcerative lesions, was the most common finding during colonoscopy. No endoscopists became infected

Read more
Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Review: Cannabis and Its Derivatives in Gastrointestinal and Hepatic Disease

Cannabis and its derivatives can have beneficial but also detrimental effects on gastrointestinal and hepatic function, via the endocannabinoid system (ECS). These are discussed in a review article in the July issue of Gastroenterology. Cannabis and its derivatives affect many gastrointestinal processes via the ECS and has reported anti-inflammatory, anti-nociceptive,

Read more

Corticosteroids, but not TNF Antagonists, Associate With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases

Increasing age, comorbidities, and use of corticosteroids and other anti-inflammatory agents correlated with severe COVID-19 in patients with inflammatory bowel diseases (IBD), whereas treatment with tumor necrosis factor (TNF) antagonists did not, researchers report in Gastroenterology. Corticosteroids, immunomodulators (thiopurines, methotrexate), and biologic agents (TNF antagonists such as infliximab) are commonly

Read more

Increased Hospitalization and Mortality in Patients With COVID-19 and Pre-existing Liver Disease

More than half of patients with COVID-19 have markers of liver injury, researchers report in Gastroenterology. However, patients with pre-existing liver disease, and even more so those with cirrhosis, have increased risks for hospitalizations and death, the study found. Shailendra Singh and Ahmad Khan studied the effects pre-existing liver disease

Read more
  • Is There a Treatment for Patients With Celiac Disease Who Accidentally Ingest Gluten?

Is There a Treatment for Patients With Celiac Disease Who Accidentally Ingest Gluten?

The oral steroid budesonide is effective in treatment of acute symptoms from gluten exposure in patients with celiac disease, researchers report in the January issue of Clinical Gastroenterology and Hepatology. The only established treatment for celiac disease is gluten avoidance. However, even when patients follow gluten-free diets, they can accidentally ingest

Read more
  • How Should We Treat Recurrent Acute Pancreatitis?

How Should We Treat Recurrent Acute Pancreatitis?

Recurrent acute pancreatitis with a clear cause can be treated with endoscopy, explain Liam Zakko and Timothy B. Gardner in a “Here and Now: Clinical Practice” article in the October issue of Clinical Gastroenterology and Hepatology. Acute pancreatitis affects 40 to 50 of every 100,000 Americans per year and is the

Read more

Herpes Esophagitis Can Resemble Candidiasis

A patient who initially appeared to have Candida esophagitis was later found to have herpes esophagitis, based on findings from endoscopy. Gastroenterologists who observe this type of lesion should consider disorders other than candidiasis. Joyce Chivia and Pedro C. Figueiredo describe a 73-year-old man with bilateral pneumonia and treated with piperacillin and

Read more
  • How Does Gastric Adenocarcinoma Develop?

How Does Gastric Adenocarcinoma Develop?

Overexpression of the peroxisome proliferator-activated receptor delta (PPARD) in gastric progenitor cells results in inflammation, dysplasia, and tumor formation in mice, researchers report in the July issue of Gastroenterology. Strategies to reduce PPARD in gastric progenitor cells might lead to treatments for stomach cancer. Gastric carcinogenesis is associated with chronic inflammation. The

Read more
  • Why Are Patients Cured of HCV Infection Still at Risk for Liver Cancer?

Why Are Patients Cured of HCV Infection Still at Risk for Liver Cancer?

Chronic infection with the hepatitis C virus (HCV) causes epigenetic changes in liver cells that alter gene expression patterns and continue to affect risk for hepatocellular carcinoma (HCC), regardless of patients’ response to direct-activating antiviral (DAA) agents, researchers report in the June issue of Gastroenterology. These alterations might be targeted

Read more