• A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis

A Forward Genetic Screen Identifies Suppressors of Hepatocellular Carcinogenesis

Using 2 powerful high-throughput in vivo screening tools, researchers identified and validated 27 genes as suppressors of hepatocellular carcinoma (HCC), reported in the August issue of Gastroenterology. Their findings support the role of Ras signaling in development of HCC and provide new therapeutic targets. Sorafenib is the only treatment for patients

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  • A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

A Nanoparticle-based Approach to Selectively Target Hepatocellular Carcinomas

Researchers have created nanoparticles that selectively kill hepatoma cells and reduce growth of liver tumors in rats, they report in the February issue of Gastroenterology. They show that the particles induce tumor-specific necrosis by selectively disrupting redox balance within cancer cells. Dietary intake of the natural omega-3 fatty acid docosahexaenoic

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  • Special Issue: Managing Patients With Liver Disease

Special Issue: Managing Patients With Liver Disease

A special issue of Clinical Gastroenterology and Hepatology is dedicated to the clinical management of hepatic disorders, including nonalcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune hepatitis, and primary sclerosing cholangitis (PSC). The issue comprises 14 review articles that aim to present clinicians with evidence-based guidance and expert opinions on management of patients with liver

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  • What is This Liver Tumor?

What is This Liver Tumor?

Researchers describe a rare liver tumor of vascular origin in the May issue of Clinical Gastroenterology and Hepatology. Laisa Socorro Briongos-Figuero and Tomás Zamora-Martínez describe the case of a 59-year-old man with chronic pancreatitis who was was admitted to the hospital with vomiting and jaundice, without fever or diarrhea. He had a previous history of

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What is Intrahepatic Cholangiocarcinoma?

Researchers have found that intrahepatic cholangiocarcinomas (ICCs) are really 2 different groups of tumors, based on molecular and genetic analyses, reported in the April issue of Gastroenterology. These findings identify class-specific mechanisms of oncogenesis that could lead to new treatment approaches for this common liver cancer. Cholangiocarcinoma is the second most

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Differences in HCV Infection, and Effects of Treatment, Among Countries

Hepatitis C virus (HCV) infections have developed and spread at different rates in different countries, affecting outcomes of therapy, according to the October issue of Gastroenterology. Specific details of each population must therefore be considered in designing prevention and treatment programs. Although there are many treatment options for HCV infection,

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An HIV Protein and Telomerase Inhibitor Join Forces Against Cancer

Researchers have found a way to specifically kill liver cancer cells and stop tumor growth. In the January issue of Gastroenterology, Guangming Chen et al. report that fusion of a natural inhibitor of telomerase to an HIV protein stops proliferation of hepatocellular carcinoma (HCC) cells and growth of liver tumors

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Coffee, Beyond Caffeine

Coffee—caffeinated or decaffeinated—protects liver and gastrointestinal cells from toxic compounds, according to Sandra Kalthoff et al. in the November issue of Gastroenterology. In many epidemiology studies, coffee consumption reduced the risk of inflammation, chronic liver diseases, hepatocellular carcinoma (HCC), and other GI disorders. Its mechanisms are unclear, however, because coffee

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