Does Thiopurine Therapy for IBD Increase Risk of Acute Myeloid Leukemias and Myelodysplastic Syndromes?

Past exposure to thiopurines increases the risk of myeloid disorders 7-fold among patients with inflammatory bowel diseases (IBDs), according to a prospective study in the August issue of Clinical Gastroenterology and Hepatology. Physicians should consider this finding when placing patients on thiopurine therapy, to best calculate risks and benefits. Despite

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Does Thiopurine Therapy Increase Cancer Risk?

Patients with ulcerative colitis (UC) have a 4-fold increase in risk of lymphoma during treatment with thiopurines, compared to UC patients who have not been treated with these drugs, according to a nationwide cohort study in the November issue of Gastroenterology. The risk increases gradually with successive years of therapy,

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