Gastro’s Top 20 Articles of 2020

Gastro’s Top 20 Articles of 2020

The Gastroenterology Board of Editors has compiled a list of the Top 20 gastroenterology and hepatology articles published, from any journal, in 2020. The list was created based on a survey of Gastroenterology’s diverse, international Board of Editors for their favorite articles of the past year—those that were most influential, novel, and

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  • Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Alterations in Fecal Fungal Microbiomes of Patients With COVID-19

Patients hospitalized with COVID-19 have alterations in their fecal mycobiomes, including enrichment of fungal pathogens from the genera Candida and Aspergillus, compared with controls researchers report in the October issue of Gastroenterology. Unstable gut mycobiomes and prolonged dysbiosis persisted in a subset of patients with COVID-19 for as long as 12 days after nasopharyngeal

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  • How Is The Intestinal Microbiome Altered in Patients With IBD and Does it Change During Therapy?

How Is The Intestinal Microbiome Altered in Patients With IBD and Does it Change During Therapy?

Treatment of inflammatory bowel diseases (IBD) with anti-tumor necrosis factor (anti-TNF) drugs restores diversity to the intestinal microbiome, researchers report in the November issue of Gastroenterology.  The study associates metabolic interactions among luminal bacteria with outcomes of therapy. Altered interactions between the mucosal immune system and intestinal microbiota contribute to

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  • VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

VIDEO: Non-invasive Detection of Early- and Late-Stage PDAC

Specific patterns of volatile organic compounds (VOCs) in urine samples can identify patients with pancreatic ductal adenocarcinoma (PDAC), researchers report in the February issue of Gastroenterology. The noninvasive technology, based on ion mobility spectrometry, can be used to discriminate between healthy individuals vs individuals with early- or advanced-stage cancer. VOCs are metabolic products of microbes that can

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  • Model: Microfabricated Crypt Scaffolds for Studying Human Colon Stem Cells

Model: Microfabricated Crypt Scaffolds for Studying Human Colon Stem Cells

Researchers created an in vitro human colon crypt array that provides an accurate representation of human intestinal crypts, reported in the February issue of Cellular and Molecular Gastroenterology and Hepatology. This system re-creates an intestinal epithelium with a high density of polarized crypts that respond in a physiologic manner to growth factors, metabolites, or

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  • Intestinal Microbes as Carcinogens

Intestinal Microbes as Carcinogens

Fecal microbiota from patients with colorectal cancer (CRC) have carcinogenic properties, researchers report in the December issue of Gastroenterology. Feeding mice stool from patients with colorectal cancer (CRC) increased numbers of polyps, levels of intestinal dysplasia and proliferation, and markers of inflammation in colon, compared with stool from individuals without CRC, the scientists found.

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  • Does Enhanced Sterilization of Duodenoscopes Reduce Contamination?

Does Enhanced Sterilization of Duodenoscopes Reduce Contamination?

A comparison of duodenoscopes reprocessed by standard high-level disinfection (sHLD) vs double high-level disinfection (dHLD) and standard high-level disinfection followed by ethylene oxide gas sterilization (HLD–ETO) found no significant differences in contamination with multidrug-resistant organisms (MRDO) or other bacteria. The article, published in the October issue of Gastroenterology, concludes that enhanced disinfection

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  • What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

What are the Effects of Prednisolone in Patients With Severe Alcoholic Liver Disease?

Infections are frequent in patients with severe alcoholic liver disease, but are only independently associated with mortality when patients receive prednisolone, researchers report in the April issue of Gastroenterology. This could offset prednisolone’s therapeutic benefit. This study’s senior author, Mark Thursz, discusses the findings in a video abstract. As with

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  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

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  • What is the Active Ingredient in FMT for CDI?

What is the Active Ingredient in FMT for CDI?

Sterile fecal filtrates—containing bacterial debris, proteins, antimicrobial compounds, metabolic products, and microbial DNA, rather than intact microorganisms—appear to be effective for treatment of recurrent Clostridium difficile infection (CDI), researchers report in the March issue of Gastroenterology. Fecal microbiota transplantation (FMT) is an effective therapy of recurrent CDI—a single treatment resolves

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