A More Effective Treatment for Achalasia

A specialized endoscopic procedure called peroral endoscopic myotomy (POEM) is a safe and effective treatment for esophageal achalasia, according to the August issue of Gastroenterology. Achalasia is an esophageal motility disorder characterized by incomplete relaxation of the lower esophageal sphincter, increased sphincter tone, and disrupted peristalsis. It causes dysphagia, regurgitation,

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What Causes Familial Visceral Myopathy?

A heterozygous variant in enteric smooth muscle actin γ-2 (ACTG2) can cause familial visceral myopathy (FVM), according to the December issue of Gastroenterology. The altered gene product appears to aggregate, rather than form actin filaments, in intestinal smooth muscle cells, disrupting their contraction and reducing bowel motility. FVM is a rare

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