Sensitizing Colorectal Tumors to Chemotherapy

Although colorectal tumors with microsatellite instability (MSI) are usually considered to have a poor response to 5-fluorouracil–based chemotherapy, researchers have identified a subset that actually respond well to chemotherapy. These tumors express a dominant-negative form of the chaperone HSP110, according to the February issue of Gastroenterology. Colorectal cancer (CRC) is

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