• REVIEW: How Does Barrett’s Esophagus Develop?

REVIEW: How Does Barrett’s Esophagus Develop?

Mechanisms of Barrett’s esophagus (BE) pathogenesis are discussed in a review article by Jianwen Que et al in the August issue of Gastroenterology, including cell transdifferentiation and transcommitment. The authors discuss potential cells of origin for Barrett’s metaplasia, and the possibility that there could be more than 1 type of BE

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  • Hazards of Very Hot Coffee

Hazards of Very Hot Coffee

Persistent drinking of very hot coffee can cause exfoliative esophagitis due to thermal injury, researchers report in the November issue of Clinical Gastroenterology and Hepatology. Florian Schertl et al describe the case of a 55-year-old woman with new retrosternal pain upon swallowing. She had been receiving continuous and successful proton pump inhibitor

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  • Does Mucosal Inflammation Cause Diverticulosis?

Does Mucosal Inflammation Cause Diverticulosis?

Despite limited evidence that a chronic state of low-grade mucosal inflammation contributes to development of diverticulosis, a prospective study published in the June issue of Clinical Gastroenterology and Hepatology found no correlation of the disease with mucosal inflammation, upregulated immune markers, or gastrointestinal symptoms. Colonic diverticulosis (outpouchings from the colonic lumen) is

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Gastroenterology Special Issue on Endoscopy

A special issue of Gastroenterology, Advances in Endoscopic Therapy, presents the latest advances in gastrointestinal endoscopy, including endoscopic images and videos. In their introductory article, Jacques J. Bergman and Patrick S. Yachimski explain that endoscopy is central to gastroenterology clinical practice and research, allowing examination of healthy and diseased tissue from the organ level, to the

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Video: Prick Test to Identify Allergens That Cause Esophageal Sensitization

An esophageal prick test, in which allergens are injected directly into the esophageal mucosa, appears to identify individuals with esophageal sensitization, researchers report in the January issue of Gastroenterology. In patients with eosinophilic esophagitis (EoE), food allergens are believed to induce an inflammatory response that can make swallowing and eating a challenge. Identifying and

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  • Does Good Oral Health Increase Risk for IBD?

Does Good Oral Health Increase Risk for IBD?

A population-based cohort study of more than 20,000 people in Sweden associated poor oral health with reduced risk for inflammatory bowel diseases (IBD). The article, in the April issue of Clinical Gastroenterology and Hepatology, reports that the protective effect increases with the severity of poor dental hygiene. Environmental factors, such as

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How Does an Antibiotic Reduce Symptoms of IBS?

Rifaximin alters the intestinal microbiota to prevent inflammation and visceral hyperalgesia in stressed rats, according to the February issue of Gastroenterology. These findings could explain the ability of this antibiotic to relieve symptoms of irritable bowel syndrome (IBS) in patients. Rifaximin is a broad-spectrum antibiotic that has been approved by

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Transplanting Engineered Mucosal Tissue into the Esophagus

Researchers have engineered tissues from oral epithelial cells that can be transplanted into the esophagus and promote healing after tumors are removed. According to the September issue of Gastroenterology, sutureless, endoscopic transplantation of sheets of autologous oral mucosal epithelial cells safely and effectively promotes re-epithelialization of the esophagus after surgery.

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Does Mucosal Healing Determine Which Patients Will Recover From Ulcerative Colitis?

Lack of mucosal healing, based on endoscopic analysis, identifies patients with ulcerative colitis (UC) who are not likely to respond to corticosteroid therapy, according to Sandro Ardizzone et al. in the June issue of Clinical Gastroenterology and Hepatology. In a prospective study, Ardizzone et al. followed 157 patients with moderate

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Tracking Crohn’s Therapy

Measuring blood levels of C-reactive protein (CRP), a marker of inflammation, is a good way to monitor recovery from Crohn’s disease (CD) in patients being treated with infliximab, according to Matthias Jürgens et al. in the May issue of Clinical Gastroenterology and Hepatology. CRP is a protein released into the blood

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