• How Does Gastric Adenocarcinoma Develop?

How Does Gastric Adenocarcinoma Develop?

Overexpression of the peroxisome proliferator-activated receptor delta (PPARD) in gastric progenitor cells results in inflammation, dysplasia, and tumor formation in mice, researchers report in the July issue of Gastroenterology. Strategies to reduce PPARD in gastric progenitor cells might lead to treatments for stomach cancer. Gastric carcinogenesis is associated with chronic inflammation. The

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A New Drug for Diabetes and Fatty Liver Disease?

Obeticholic acid (OCA)—an agonist of the farnesoid X receptor (FXR)— increases insulin sensitivity and reduces markers of liver inflammation and fibrosis in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), according to a study published in the September issue of Gastroenterology. Type 2 diabetes mellitus and

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