• Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Low Risk of Severe COVID-19 in Children With Inflammatory Bowel Diseases

Pediatric patients with inflammatory bowel diseases (IBD) have a low risk of severe COVID-19, even when receiving biologic and/or other immune suppressive therapies, researchers report in Clinical Gastroenterology and Hepatology. These findings support recommendations to continue maintenance IBD treatment for pediatric patients throughout the currentpandemic. SARS-CoV2 enters human cells via

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Use of Famotidine Associated With Improved Outcomes of Hospitalized COVID-19 Patients

In patients hospitalized with COVID-19 and not initially intubated, use of famotidine is associated with a 2-fold reduction in clinical deterioration leading to intubation or death, a retrospective study in Gastroenterology showed. Famotidine is a histamine-2 receptor antagonist that suppresses gastric acid production. In vitro, famotidine inhibits HIV replication, and a

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  • Summer Edition of the AGA Clinician’s Companion

Summer Edition of the AGA Clinician’s Companion

The summer edition of the AGA Clinician’s Companion—the new go-to resource for busy clinicians who can’t afford to spend hours sifting through research to find clinical value—is out! This latest edition of the AGA Clinician’s Companion, published online quarterly, summarizes research findings most relevant to clinicians on the risk of

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Addition of Nucleic Acid Polymers Improves Outcomes of Patients With HBV Infection

Addition of nucleic acid polymers (NAPs), which inhibit assembly and secretion of hepatitis B virus (HBV) subviral particles, to tenofovir disoproxil fumarate (TDF) and pegIFN therapy significantly increased rates of HBsAg loss and seroconversion, and functional cure, after therapy, researchers report in Gastroenterology. Chronic HBV infection causes progressive liver fibrosis,

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Increased Hospitalization and Mortality in Patients With COVID-19 and Pre-existing Liver Disease

More than half of patients with COVID-19 have markers of liver injury, researchers report in Gastroenterology. However, patients with pre-existing liver disease, and even more so those with cirrhosis, have increased risks for hospitalizations and death, the study found. Shailendra Singh and Ahmad Khan studied the effects pre-existing liver disease

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REVIEW: Transitioning Adolescents With Inflammatory Bowel Diseases to Adult Care

Adolescents and young adults diagnosed with inflammatory bowel diseases (IBDs) in pediatric care are vulnerable during their transition to adult care. A review article in the February issue of Clinical Gastroenterology and Hepatology discusses the transition from pediatric to adult care for IBD, makes recommendations to improve this process, and identifies

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  • Does Placement on a Distant Liver Waitlist Increase Chances of Transplantation?

Does Placement on a Distant Liver Waitlist Increase Chances of Transplantation?

Placement on a liver transplant waitlist outside of a patient’s home region can reduce mortality and increase odds of receiving a liver, researchers report in the October issue of Clinical Gastroenterology and Hepatology. Strategies are needed to overcome geographic differences in access to livers for transplantation, which are more likely

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  • What Happens When You Have Dysphagia After Anti-Reflux Surgery?

What Happens When You Have Dysphagia After Anti-Reflux Surgery?

In patients who develop dysphagia within a few weeks after fundoplication surgery for gastroesophageal reflux disease (GERD), most symptoms resolve with time and require no intervention. However, patients with clinically significant dysphagia months after this surgery benefit from endoscopic dilation, researchers report in the September issue of Clinical Gastroenterology and

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Is an Endoscopic Transluminal Approach Better Than Surgery for Patients With Necrotizing Pancreatitis?

An endoscopic transluminal approach for treatment of infected necrotizing pancreatitis, compared with minimally invasive surgery, significantly reduced major complications, lowered costs, and increased quality of life, according to a randomized trial published in the March issue of Gastroenterology. Acute pancreatitis is the third most common gastrointestinal disorder in the United

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  • Has MELD-Na Improved Outcomes of Patients on the Liver Transplant Waitlist?

Has MELD-Na Improved Outcomes of Patients on the Liver Transplant Waitlist?

Liver allocation based on model for end-stage liver disease-sodium (MELD-Na) score improved waitlist outcomes and provided significant benefit to patients with hyponatremia, researchers report in the November issue of Gastroenterology. However, there are discrepancies in transplantation survival benefit, so current rules for liver allocation might require revision, the authors state. The

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