• How Might PPIs Promote C difficile infection?

How Might PPIs Promote C difficile infection?

Proton pump inhibitors (PPIs) do not have a large effect on microbial diversity of the colon, but do affect specific taxa, including Streptococcaceae and Enterococcaceae, which mediate resistance to Clostridium difficile infection (CDI), researchers report in the October issue of Gastroenterology. This finding might provide a mechanism by which these drugs increase risk for CDI.

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Can Proton Pump Inhibitors Prevent Esophageal Cancer?

Proton-pump inhibitor (PPI) therapy reduces risk of esophageal cancer in patients with Barrett’s esophagus (BE), according to the April issue of Clinical Gastroenterology and Hepatology. In BE, the squamous epithelium of the distal esophagus is replaced by metaplastic columnar epithelium, as a result of chronic exposure to stomach acid. Patients

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Which Therapy for Helicobacter pylori Infection?

A combination of esomeprazole and 3 antimicrobial agents is less expensive and complex, and equally or more effective, than sequential regimens for eradication of  Helicobacter pylori infection, according to the July issue of Gastroenterology. H pylori infection causes stomach cancer in 20% of infected subjects, so it is important to eliminate. Although

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