Stomach Botox for Weight Loss?

Gastric injections of botulinum toxin A (BTA) can delay gastric emptying but do not make obese individuals feel more full, alter their eating behaviors, or cause them to lose weight, according to the February issue of Clinical Gastroenterology and Hepatology. In attempts to help people lose weight, researchers have tested

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Does a Response to Proton Pump Inhibitor Therapy Indicate GERD?

Just because a patient’s upper gastrointestinal symptoms are alleviated by proton pump inhibitors (PPIs) doesn’t necessarily mean that they have gastroesophageal reflux disease (GERD), according to the December issue of Clinical Gastroenterology and Hepatology. The efficacy of PPI therapy often is tested to determine whether patients’ symptoms are acid-related and

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How do Intestinal Stem Cells get their Wnt?

Intestinal homeostasis and stem cells are not affected when Paneth cells stop producing Wnt, but Wnt is required to maintain the stem cell niche in intestinal epithelial cultures, according to a mouse study in the December issue of Gastroenterology. These findings indicate that underlying mesenchymal cells provide a secondary physiological

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How Dangerous Are H pylori-Negative Idiopathic Bleeding Ulcers?

Patients with a bleeding peptic ulcer not caused by Helicobacter pylori infection or non-steroidal anti-inflammatory drugs (NSAIDs) are at considerable risk of recurrent bleeding and death. Furthermore, acid-suppressive drugs do not protect these patients, according to the October issue of Clinical Gastroenterology and Hepatology. Peptic ulcers that are not associated

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Can Antioxidants Reduce Pain from Chronic Pancreatitis?

A randomized, placebo-controlled trial published in the September issue of Gastroenterology found that antioxidants do not reduce pain or improve quality of life in patients with chronic pancreatitis—at least for middle-aged patients with alcohol- or smoking-related disease. Chronic pancreatitis is characterized by inflammation of the pancreas, with loss of normal

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What Happens After Patients are Diagnosed With Celiac Disease?

Most patients with celiac disease are not adequately followed, according to the August issue of Clinical Gastroenterology and Hepatology (CGH). Improving follow-up strategies for patients with celiac disease could improve their outcomes. Adherence to a gluten-free diet is the only effective treatment for celiac disease. This is a difficult diet

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Many Patients Without GERD Continue to Take PPIs

More than 42% of patients with negative results from pH monitoring studies continue proton pump inhibitor (PPI) therapy, despite evidence that they do not have gastroesophageal reflux disease (GERD), according to the June issue of Clinical Gastroenterology and Hepatology. PPI therapy is effective for about 75% of patients with GERD

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A Special Issue on Viral Hepatitis

The May issue of Gastroenterology features a very special supplement—“Viral Hepatitis: A Changing Field”—comprising 17 review and commentary articles from international leaders in hepatitis treatment and research. The issue provides insight into the rapid progress made in the treatment and management of patients with viral hepatitis, as well as our

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Is Cardiac Surgery Safe for Patients With Cirrhosis?

Patients with compensated cirrhosis who undergo cardiac surgery with cardiopulmonary bypass do not have greater post-operative mortality or morbidity than other patients who receive this surgery, according to the May issue of Clinical Gastroenterology and Hepatology. Advanced liver disease is a significant risk factor for complications after cardiac surgery, but

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Is Medicine or Surgery the Best Treatment for Crohn’s Disease?

For patients with Crohn’s disease and intra-abdominal abscesses, nonsurgical and surgical management strategies result in similar rates of abscess recurrence and complications, according to the April issue of Clinical Gastroenterology and Hepatology. Crohn’s disease can progress from inflammation and ulceration to bowel damage that includes formation of abscesses, phlegmon, and

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