Can We Prevent Portal Vein Thrombosis in Patients With Cirrhosis?

The anti-clotting agent enoxaparin prevents portal vein thrombosis (PVT) in patients with cirrhosis, according to the November issue of Gastroenterology. PVT can lead to portal hypertension and reduce the blood supply to the liver—some patients with acute or extensive PVT develop severe gastrointestinal bleeding, ascites, or intestinal ischemia, which can progress and become

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What Can We Learn from a Pig Model of FAP?

A pig model of intestinal adenoma development, described in the November issue of Gastroenterology, will improve our understanding of colorectal cancer development and could be used to evaluate new therapeutics. Familial adenomatous polyposis (FAP) is an inherited disease; patients develop dysplasias in the colon and rectum that develop to adenomatous

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How Dangerous Are H pylori-Negative Idiopathic Bleeding Ulcers?

Patients with a bleeding peptic ulcer not caused by Helicobacter pylori infection or non-steroidal anti-inflammatory drugs (NSAIDs) are at considerable risk of recurrent bleeding and death. Furthermore, acid-suppressive drugs do not protect these patients, according to the October issue of Clinical Gastroenterology and Hepatology. Peptic ulcers that are not associated

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Can Antioxidants Reduce Pain from Chronic Pancreatitis?

A randomized, placebo-controlled trial published in the September issue of Gastroenterology found that antioxidants do not reduce pain or improve quality of life in patients with chronic pancreatitis—at least for middle-aged patients with alcohol- or smoking-related disease. Chronic pancreatitis is characterized by inflammation of the pancreas, with loss of normal

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Causes and Treatment of Very-Early Onset IBD

Many infants with inflammatory bowel disease (IBD) have genetic defects that disrupt IL-10 signaling, according to the August issue of Gastroenterology. However, these children can be successfully treated by allogeneic hematopoietic stem cell transplantation, researchers report. IBD develops mostly in adolescents and young adults, but can occur in very young

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Which Direction is Best for Enteroscopy?

Antegrade is better than retrograde enteroscopy in diagnosis and treatment of patients with small bowel disease, according to the August issue of Clinical Gastroenterology and Hepatology. Single and double balloon-assisted enteroscopy (SBE and DBE), and spiral enteroscopy (which uses a screw-like overtube), are used to evaluate and treat patients with

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Eosinophilic Esophagitis? Change Your Diet.

Eliminating specific foods from your diet can reduce symptoms of eosinophilic esophagitis (EoE), according to the June issue of Gastroenterology. EoE is an immune disorder in which eosinophils cause inflammation of the esophagus, leading to difficulty swallowing and food impactions. Many adults cope for years with swallowing difficulties and do

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Many Patients Without GERD Continue to Take PPIs

More than 42% of patients with negative results from pH monitoring studies continue proton pump inhibitor (PPI) therapy, despite evidence that they do not have gastroesophageal reflux disease (GERD), according to the June issue of Clinical Gastroenterology and Hepatology. PPI therapy is effective for about 75% of patients with GERD

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A Special Issue on Viral Hepatitis

The May issue of Gastroenterology features a very special supplement—“Viral Hepatitis: A Changing Field”—comprising 17 review and commentary articles from international leaders in hepatitis treatment and research. The issue provides insight into the rapid progress made in the treatment and management of patients with viral hepatitis, as well as our

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Is Cardiac Surgery Safe for Patients With Cirrhosis?

Patients with compensated cirrhosis who undergo cardiac surgery with cardiopulmonary bypass do not have greater post-operative mortality or morbidity than other patients who receive this surgery, according to the May issue of Clinical Gastroenterology and Hepatology. Advanced liver disease is a significant risk factor for complications after cardiac surgery, but

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